Studying the Effect of Furosemide Injection on Pulmonary Artery Parameters in Dogs

Doppler ultrasonography is a suitable non-invasive method for examining vascular hemodynamics that using the Doppler effect and changing the frequency of the recoil of moving targets, the speed and direction of blood flow can be examined. The aim of this study is to evaluate the effect of Furosemide on pulmonary artery by determining vascular parameters in healthy and adult dogs.

Measurements were made by Doppler ultrasonography. In this study, 5 dogs of native breed were studied. The injection was given intramuscularly at a dose of 0.2 mg per kilogram body weight. Vascular parameters of the pulmonary artery were measured before the injection of Furosemide and at 15 and 30 minutes after drug injection. These parameters include peak systolic velocity (PSV), resistive index (RI) and Pulsatility index (PI).  

The results showed that the changes occurred 15 minutes after the injection. Thus, blood flow velocity changes from 29 to 30.5, arterial resistance index from 1.56 to 1.44 and arterial heart rate index from 52.4 to 21.4.

The results of the present study also show that the injection of Furosemide significantly increases blood flow velocity in the pulmonary artery.