Evaluation of spirometric indices, IgE and serum eosinophilia in asthmatic patients of Kashan

The spirometric indices are important values in asthmatic patients. There are some reports indicating that IgE and serum eosinophilia could help to interpret spirometric status. The aim of this study was to determine spirometric indices, IgE and serum eosinophilia of asthmatic patients in Kashan. 154 patients were enrolled in this descriptive study. They were referred to a private clinic and Shaheed Beheshti hospital in Kashan. These patients were examined for spirometry, total serum IgE and eosinophilic count. Patients were assigned according to <5% eosinophilia, >5% eosinophilia and also IgE <150U/ml and IgE >150U/ml. Groups were compared with t-test. The study population included 76 male and 78 females with the mean age of 34.8 ± 16.8 years. Spirometric indices and serum IgE did not show a significant association (NS). FEV1 was 73.8 ± 21.6 in patients with <5% eosinophilia and was 62.9 ± 19.4 in patients with >5% eosinophilia (p<0.01). Other spirometric indices did not show a significant association with eosinophilia status. FEF25-75% did not differ significantly between groups (NS). In middle-ages asthmatic patients spirometric indices do not correlate with patient's IgE status. There is a reverse relation between IgE and spirometric indices except for FEF. Further studies are strongly recommended.