The Effect of Magnesium Oxide Nanoparticles on Oxidative Stress in a Parkinson's Model of Male Rats

Since limited studies have evaluated the antioxidant effects of magnesium oxide nanoparticles on Parkinson's disease, the aim of this study is to investigate the effect of magnesium oxide nanoparticles (MON) on oxidative stress in the Parkinson's model in mice. In this experimental study, 54 adult male rats were divided into nine groups of six, including: healthy control group, parkinsonian control group receiving 6-hydroxydopamine in the lateral ventricle, sham group receiving normal saline and healthy experimental group receiving magnesium oxide nanoparticles in doses of 2.5, 5 and 10 mg/kg and experimental Parkinson's groups that in addition to inducing Parkinson's, received magnesium oxide nanoparticles in doses of 2.5, 5 and 10 mg/kg. Administration of nanoparticles was intraperitoneal for 30 days. After that, oxidative stress parameters MDA, CAT and SOD were measured in the brain tissue. The results of the present study showed that treatment with magnesium oxide nanoparticles significantly reduced the amount of oxidative stress parameters in the brain tissue (p < 0.05). Magnesium oxide nanoparticle treatment in doses of 5 and 10 mg/kg decreased MDA in parkinsonian groups compared to parkinsonian control animals. Also, the treatment of magnesium oxide nanoparticles in doses of 5 and 10 mg/kg in the parkinsonian group caused a significant increase in the activity of SOD and CAT enzymes compared to parkinsonian control animals. As a result, it can be said that magnesium oxide nanoparticle can play a promising role with its effectiveness in reducing oxidative stress processes in Parkinson's model.