Comparison of PFS-OS between two treatment methods (surgery and then chemotherapy compared with neoadjuvant and then surgery) in patients with endometrial cancer: a retrospective study

Endometrial cancer is one of the common diseases among women, which causes the death of many women in the world every year. The survival of patients and their response to treatment is determined based on clinical conditions and the stage of the disease. It has been determined that patients who are in the advanced stage (stage III and IV) have a shorter survival. The present study was conducted with aim to evaluate the survival of patients based on OS and PFS (overall survival and progression-free survival).

Methods :

In this retrospective cohort study, all patients with advanced endometrial cancer who were treated in Firouzgar and Rasoul Akram hospitals during the last 8 years from 2010 to 2018 were compared in two groups with different treatment methods (first neoadjuvant therapy and then surgery compared to first surgery and then adjuvant therapy). Data were analyzed by Stata software (version 14.1). The survival rate of patients was evaluated using the Kaplan-Meier approach. Factors affecting the survival rate were also analyzed using a Cox regression model. The investigation of factors affecting the response to treatment was also done in a multiple logistic regression model. P< 0.05 was considered statistically significant.

There was no significant difference in terms of mean survival in patients who were treated with chemotherapy surgery and surgical chemotherapy (p>0.05). Total survival rate was higher in patients treated with standard method compared to patients who received chemotherapy first and then surgery.

There was no significant difference in the survival of patients in terms of treatment with chemotherapy surgery and surgical chemotherapy. However, the variable of surgery had the highest correlation in the recurrence of the disease and also the survival of the patients.