Investigation of an Increase in the Expression of the Mir146a Gene in The Hippocampus and a Decrease in the Levels of Blood Sugar, Insulin, and Insulin Resistance in Elderly Diabetic Rats after a Period of High-Intensity Interval Training
MicroRNAs have been reported as potentially valuable biomarkers for various diseases, including diabetes, heart diseases, neurological diseases, and age-related diseases. The present study aimed to investigate the effect of 8 weeks of intense intermittent exercise on the expression of mir146a, blood sugar, insulin, and insulin resistance in the hippocampus of aged diabetic male rats.
This study was performed on 40 male Wistar rats aged 18-21 months with an average weight of 280±20 g. After becoming diabetic through streptozotocin solution, they were randomly divided into 4 groups, including 1) healthy high-intensity interval training (HIIT) exercise, 2) healthy control, 3) diabetic HIIT exercise, and 4) diabetic control. It should be mentioned that each group included 10 rats. The exercise groups exercised 5 days a week according to the HIIT programs for 8 weeks. The collected data were analyzed using GraphPad Prism software (version 8) at a significance level of P<0.05.
The results showed that 8 weeks of HIIT exercise increased the expression of mir146a in both of the exercise groups, compared to the diabetic control group (P<0.001). Moreover, the blood sugar, insulin, and insulin resistance levels significantly decreased in the diabetic exercise, healthy HIIT exercise, and healthy control groups, compared to the diabetic control group (P<0.001).
It can be concluded that 8 weeks of HIIT training, which increased the expression of mir146a, can reduce neuronal destruction in the hippocampus region. Moreover, it can be used as a suitable non-therapeutic mechanism for diabetics to prevent or reduce damage in this brain region that is related to cognitive abilities.
Aging , Diabetes , Hippocampus , Mir146a
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