Evaluation of the sedative effect of intravenous lidocaine in patients undergoing Endoscopy with Propofol-Ketamine; a randomized clinical trial

Gastrointestinal endoscopy is a suitable diagnostic and therapeutic method for gastrointestinal diseases and choosing a suitable sedation method for this procedure is important. Sedation with propofol-ketamine is one of the most commonly used methods. This study was designed to evaluate intravenous lidocaine in endoscopy under sedation.

The designed study is a double-blind clinical trial that was conducted on 138 patients candidates for outpatient endoscopy after approving the proposed plan and obtaining approval from the Medical Ethics Committee of Ahvaz Jundishapur University of Medical Sciences. Patients were divided into two groups. In the first group, 0.5 mg/kg of propofol and 0.5 mg/kg of ketamine were, and in the second group, the same drugs and 1.5 mg/kg of lidocaine were injected. The level of sedation, nausea, vomiting and hemodynamic changes in the patients were recorded and compared.

The two groups were matched for age, gender, and weight. There was no significant difference in the duration of the endoscopy. . There was no significant relationship between the heart rate and mean arterial pressure in the two groups(p>0.05). There was no significant difference in recovery time between the two groups. The amount of additional propofol was significantly lower in the group receiving lidocaine The level of sedation did not differ between the two groups, and nausea and vomiting were significantly lower in the group receiving lidocaine.

Adding intravenous lidocaine to a propofol-ketamine combination improves clinical outcomes and reduces side effects.