The effect of rest interval between sets during bouts of eccentric exercise on serum levels of TNF-α in untrained men

Various studies have demonstrated that different rest Intervals has a significant effect on hormonal, metabolic and cardiovascular responses. This factors can lead to different muscle damage responses.

20 untrained subjects (25.4 ± 0.068 years, height 1.74 ± 0.97 cm and weight 30.8 ± 8.48 kg) in three sessions of eccentric resistance exercise with 24 hours rest between each session Participated in this study. Subjects were divided into 2 groups of 10 subjects who performed 50 eccentric contractions with number of 5 sets, 10 repetitions, and the interset rest interval 1 and 3 minutes with 85% of one repetition maximum (1RM). Alpha necrosis tumor factor, were measured immediately before , immediately after each session and 24 hours after the last training session. Variance analysis with repeated measurment and Bonferroni post- hoc test were used to statistical analysis of data.

Alpha necrosis tumor factor in the immediately after each training session and 24 hours after the last training session in 2 groups significantly increased (P <0.05), but no significant difference in All dependent variable was found in 2 groups at different time points.

The repetition of eccentric exercise for three consecutive days causes muscle damage that can be a factor influencing the immune system and causing inflammatory responses in untrained individuals independent of manipulating the interset rest intervals.