The Effect of Linalool, Cineole, Beta bourbonin and Aerobic Exercises as Protective Approaches in Mice with Alzheimer's Disease

Alzheimer's disease is a progressive neurological disorder associated with aging. The research aims to determine the effect of eight weeks of aerobic exercise and consumption of linalool, cineol and beta bourbonin on the prevention and improvement of the cognitive process of mice with Alzheimer's disease.

48 C57BL/6 female mice with an average age of 15 months were randomly divided into 8 groups of 6 each. Bioactive compounds include linalool with a concentration of 5.2 mg/kg, cineole with 100 mg/kg, beta bourbonin with a concentration of 72 mg/kg, administered by gavage, and moderate-intensity aerobic exercise for 8 weeks. Bioinformatics analysis of Bdnf, Ngf and Creb genes selected and measured by qPCR-Real Time.

The expression of Bdnf, Ngf and Creb increased in Alzheimer+ bioactive compounds, Alzheimer+ aerobic exercise and Alzheimer+ bioactive compounds + aerobic exercise compared to Alzheimer group. Aerobic exercises and consumption of bioactive compounds before induction of Alzheimer's disease enhance Bdnf, Ngf, and Creb, indicating a protective effect in Alzheimer's disease. A synergistic effect was observed in the group of bioactive compounds + aerobic exercise + Alzheimer on the expression of genes compared to other groups. In addition, the rate of new object recognition in Alzheimer + bioactive compounds + aerobic exercise compared to other groups was increased.

The decrease in Bdnf, Ngf, and Creb gene expression in the bioactive compounds+aerobic exercise+Alzheimer group was slighter than in other groups, indicating a protective effect on the process of Alzheimer's.