Evaluation of the Effects of Targeted Oxygen Therapy on the Recovery Outcomes of Patients with COVID-19 Using the Experiences and Capacities of a Military Hospital: A Randomized Clinical Trial

Oxygen therapy is one of the important topics of supportive treatment in COVID-19 patients. The present study aims of determining the effect of targeted oxygen therapy on the recovery outcomes of patients with COVID-19 in a selected military hospital in Tehran in 1400.

A single-blind clinical trial with a control and intervention group was performed on COVID-19 patients admitted to Baqiyatallah Al-Azam Hospital from October 26 to November 20, 2021. The sampling method was simply random and the sample size of 40 people in both groups was calculated. Data collection (improvement outcomes) using demographic information registration form and checklist of clinical findings (shortness of breath, respiratory retention test, six-minute walk test, laboratory tests (Troponin, CDK, LDH), chest pain, in The period at arrival was 24 hours after admission and discharge time. Data using SPSS software version 25, descriptive statistics (mean, standard deviation, and frequency), and inferential statistics (Chi-square test, paired t-test, Friedman) in 95% confidence level were analyzed.

The results of the present study showed a significant difference between the consequences of shortness of breath, systolic blood pressure, chest pain, and a six-minute walk test (P<0.05). Also, there was no significant difference in serum LDH and CPK levels between the intervention and control groups at the time of admission. But there was a significant difference in serum Tropinin level (P<0.05).

Targeted oxygen therapy has been effective as a supportive strategy to improve oxygen delivery in COVID-19 patients and reduce the consequences of this disease. Given the current need for additional supportive therapy to improve oxygen delivery, targeted oxygen therapy is recommended as a new medical supportive treatment in COVID-19 patients.