Changes in serum irisin, myonectin and insulin resistance levels in obese and overweight women: The Impact of green coffee supplement and type of exercise training

Exercise training along with green coffee consumption can be considered as an important strategy to control obesity. The aim of present study was to compare the effect of aerobic, resistance and combined exercise trainings along with green coffee supplement on serum levels of irisin, myonectin and insulin resistance in obese women.

In this quasi-experimental study, 60 women with a range of 25 ± 5 years old and body mass index of 30 ± 5 kg/m2 were purposefully selected and randomly divided into five groups (n=12) as aerobic training+supplement, resistance training+supplement, combination training+supplement, supplement and control. The intensity of aerobic training was considered 50 to 75% of the maximal heart rate and for resistance training it was 55 to 70% of one maximum repetition. Trainings were performed for three days per week during eight weeks. During the same period, green coffee was consumed at a dose of 400 mg daily before dinner. Fasting blood samples were taken 24 hours before the first training session and 48 hours after the last training session. For statistical analysis the covariance and Bonferroni tests were applied for results extraction at the significant level of p<0.05.

Serum levels of irisin and myonectin in the both exercised and consumed green coffee, significantly increased as compared to pre-exercise and other groups. Moreover, insulin resistance significantly decreased after aerobic and combination training along with supplement compared to other groups and even before pre-exercise; however, after resistance training and supplement, its amount increased compared to other groups.

All three exercises performed together with green coffee supplement, could increase myokines such as irisin and myonectin, in addition it can affecting body composition and weight losing, and also improve insulin action and reduced insulin resistance. However, combined exercise and aerobic training with supplementation produced greater improvements in insulin and insulin resistance compared to resistance training with supplementation.