Mechanisms involved in the progression of Gastric cancer caused by Helicobacter pylori

One of the most common bacterial infections is Helicobacter pylori (H.pylori), which causes chronic and progressive inflammation and is considered one of the important etiological and pathogenic factors of gastric ulcer and gastric cancer (GC). The aim of this study investigating the mechanisms related to H.pylori in causing gastric cancer.

This systematic review study was conducted based on the Prisma protocol and searching in international databases Scopus, PubMed, Google Scholar, Science Direct and national databases SID, Magiran and MedLib. According to the PICOS strategy, all articles published in Persian and English from 2011 to 2021 using the Persian keywords " Mechanism ", "Gastric Cancer" and "Helicobacter pylori" and the English equivalent of these words and the combination of these words in The search page of each of the databases in question was searched with the necessary strategy. Finally, the quality articles were evaluated based on the purpose of the study.

Based on the results, The etiology of gastric cancer is multifactorial, but with the present research, it can be said that the role of H.pylori in causing ulcer and gastric cancer is determined by mechanisms, environmental factors, and the host's immune response.

Examining the mechanisms and pathways of disease caused by Helicobacter pylori can lead to the development of newer and more effective methods for the prevention and treatment of gastric cancer.