Effect of High-Intensity Interval Training and Portulaca Oleracea Extract on C-Reactive Protein and Tumor Necrosis Factor-α in Rats with Nonalcoholic Fatty Liver Disease

The present study aimed to investigate the effect of High-Intensity Interval Training (HIIT) and Portulaca Oleracea extract on serum levels of C-Reactive Protein (CRP) and Tumor Necrosis Factor-α (TNF-α) in rats with nonalcoholic fatty liver disease (NAFLD).

A total of 25 male Wistar rats were randomly divided into five groups: healthy control, fatty liver control, Portulaca Oleracea extract, HIIT, and HIIT+Portulaca Oleracea extract. To induce NAFLD, the rats were fed a high-fat diet for 12 weeks. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for eight weeks, five sessions per week with seven repetitions of 1 minute at 90% maximum speed accompanied by active rest intervals, including 2 minutes of running at 20% maximum speed.

Serum levels of C-Reactive Protein and Tumor Necrosis Factor-α in Portulaca Oleracea extract, HIIT, and HIIT+Portulaca Oleraceagroups extract groups were significantly lower than the fatty liver control group (P<0.05).

As evidenced by the results of this study, HIIT alone and combined with Portulaca Oleracea extract can exert positive effects on liver inflammation in patients with NAFLD and prevent disease progression