The Effect of Pilates Training with Resveratrol on Serum Levels of Sestrin 2, Lipocalin 2, Oxidative Stress and Metabolic Syndrome in Obese Middle-Aged Women

Obesity is associated with metabolic syndrome and cardiovascular diseases. Sestrin-2 (SESN2) and Lipocalin 2 (LCN2) an important role in obesity and its complications. Exercise and some natural substances are known to play a valuable role in the treatment and prevention of obesity complications. The aim of this study was to investigate the effect of Pilates training (PT) and resveratrol (RSV) on SESN2, LCN2, HOMA-IR and oxidative stress in obese middle-aged women.

In this clinical trial study, 40 overweight adult men (age 42.74±5.70 years, Body mass index: BMI 31.76±1.37 kg/m2) were selected from Tehran and randomly allocated into four groups; including Placebo (C), Pilates Training (PT), Resveratrol (RSV) and Pilates Training-Resveratrol (PTRSV). PT groups performed a moderate intensity exercise program for 8 weeks, 3 times/week. The RSV and PTRSV groups were provided with 500 mg RSV tablets daily in the morning. Serum SESN2 and LCN2 levels were measured by ELISA kit. Data were analyzed using an independent t-test and ANCOVA at a significance level of p<0.05.

It was observed a significant increase in SESN2 and a decrease in LCN2 in PT groups (P=0.034, P=0.046, respectively), RSV (P=0.017, P=0.040, respectively) and PTRSV (P=0.0001, respectively), P=0.0001) compared to C; and PTRSV compared to PT (P=0.011, P=0.037) and RSV (P=0.020, P=0.023 respectively).  Also, there was a significant increase in the GPX and a decrease in HOMA-IR and MDA in the PT, RSV and PTRSV groups compared to the C group; And PTRSV compared to PT and RSV groups (p<0.05).

PT and RSV counteract obesity-induced metabolic disorders by affecting SESN2, LCN2, oxidative stress and HOMA-IR. Therefore, the combination of PT and RSV is one of the effective solutions to prevent metabolic syndrome and cardiovascular diseases in obese women.