Evaluation of CA19.9 tumor marker in early diagnosis of pancreatic cancer by Chemi Luminescencent immunoassay method

 Evaluation of CA19-9 tumor marker level as a suitable and specific marker is useful in early diagnosis and clinical management of pancreatic malignancies with new and reliable laboratory methods such as quantitative luminescence method.

 The present study was conducted with the aim of evaluating the serum level of CA 19-9 by quantitative luminescence method for the early diagnosis of PADC from other benign pancreatic diseases.

 150 serum samples including; 50 samples with PDAC in different stages of the disease, 50 samples with benign disease conditions (chronic pancreatitis) and 50 healthy samples were examined as reference and control groups based on age/sex. Data analysis was done using Spss version 18 in separate groups with logistic regression analysis, comparison of means (ANOVA) and Tukey.

 The three studied groups (healthy people with an average of 8.031, people with chronic pancreatitis with an average of 49.932, and people with pancreatic cancer with an average of 543.164 (F=231.652, P<0.0001) in terms of average statistical analysis The averages were completely different.90% of the patients were over 50 years old and there was a significant relationship between increasing age and increasing tumor marker CA19-9 (r=0.465, n=150, P=0.000).There was a weak significant relationship between the increase in CA19-9 tumor marker levels in men compared to women (r=0.166, n=150, P=0.042) and in men there was a significant increase in CA19-9 tumor marker levels (30 out of 50 people Patients with pancreatic cancer: 60%) were seen. Also, differentiation of chronic pancreatitis patients from pancreatic cancer with ROC statistical analysis at the cut-off point at 100 units/ml had 100% accuracy in identifying malignancy.

 The level of tumor marker CA 19-9, using age and gender factors, significantly distinguished healthy people from those with chronic pancreatitis and pancreatic cancer with very appropriate accuracy.