The effect of eight weeks of aerobic exercise and coriander seed extract on oxidative stress and cellular energy indices of heart tissue in male rats poisoned with hydrogen peroxide

The aim of this research was to investigate the effect of eight weeks of aerobic training and coriander seed extract with two doses of 5 and 10 mg on oxidative stress markers and cardiac muscle ATP levels of rats poisoned with hydrogen peroxide.

42 healthy adult male rats were randomly divided into 7 groups. During one week, the groups were poisoned intraperitoneally by receiving 100 mg/kg of hydrogen peroxide. In the following, the target groups were subjected to intervention on the treadmill for eight weeks (5 sessions of 60 minutes per week) with doses of 5 and 10 mg per kilogram of coriander seed extract. At the end, the concentration of ATP, MDA and PAB indicators was measured using ELISA method.

The results of analysis of variance test showed the decreasing effect of aerobic exercise on MDA and PAB values (P<0.05), while it had no significant effect on ATP concentration (P>0.05). On the other hand, consumption of two doses of coriander seed extract had no significant effect on the prooxidant-antioxidant balance (P>0.05), while their consumption caused a significant increase in ATP concentration (P<0.05).

Despite the fact that eight weeks of aerobic exercise is considered a suitable solution for modulating the changes in oxidative indices caused by hydrogen peroxide poisoning, this intervention does not have a significant effect on the amount of myocardial cellular energy. On the other hand, the effects of coriander seed extract are probably dose-dependent in some cases.