Vitamin E reduces kidney damage caused by ecstasy in mice

Ecstasy is one of the most famous derivatives of amphetamine The aim of the present study was evaluating the effects of vitamin E on ecstasy- induced kidney histological damages in mice.

Methods and Materials: 

28 male albino mice were divided into four groups. The control group, the ecstasy group (10 mg/kg ecstasy intraperitoneally), the ecstasy group + vitamin E 150 mg/kg through gavage), the vitamin E solvent group (olive oil) for five weeks. Kidny tissues were evaluated histologically by H&E and Masson’s trichrom staining methods. Urea and creatinine levels were also measured in serum.

Tissue changes were indicative of kidney tissue disorder in the ecstasy group. Evaluation of renal fibrosis showed that in the ecstasy group, large areas of fibrosis were seen in the kidney tissue, as well as in the glomerular structure and renal tubules. On the other hand, the degree of fibrosis in the group receiving vitamin E was significantly lower than in the ecstasy group. Also, taking ecstasy caused a significant increase in serum creatinine and urea compared to the control group. But the vitamin E improved these conditions.

Ecstasy consumption can lead to glomerular infiltration, Bowman capsule injury and renal fibrosis. In contrast, the use of vitamin E treatment after taking ecstasy can significantly inhibit the progression of injury.