An Investigation into the Effects of Water- and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases

Neurodegenerative diseases (ND) cause several disruptions in the neuronal function in the brain, resulting in cognitive disorders as well as motor neuron disabilities. Although several factors contribute to the development of these diseases, nutrients could play an important role in their pathogenesis. Nutritional deficiencies or imbalances in vitamins regulation may influence neurological metabolism and lead to abnormal functions in the brain, such as oxidative stress production, mitochondrial dysfunction, and protein accumulation (Synuclein, β amyloid plaques). This may eventually lead to ND. Water- and fat-soluble vitamins not only may prevent Parkinson's and Alzheimer's diseases but also have therapeutic effects on these diseases via their antioxidant and anti-inflammatory properties. However, some studies indicate that vitamin function does not influence on prevention of ND.

Regarding to neurological protection role of water- and fat-soluble vitamins, in this review article, we have summarized the role of the neuroprotective effects of vitamins on ND.