Effect of Adding Zirconium Oxide Nanoparticles on the Growth and Adhesion of Candida Albicans in the Injection Mold Acryls

Adhesion to the surface of denture is a unique feature of oral candidiasis. Nanoparticles have antifungal and antibacterial properties that can be used in the structure of the dentures along with acrylic. The purpose of this study was to examine the inhibitory effect of zirconium oxide nanoparticles on the growth and adhesion of Candida albicans in the injection mold acryls. Materials &

In this experimental laboratory study, 90 acrylic blocks were prepared using the injection molding technique. The acrylic blocks were divided into three groups of 0, 2.5, and 7.5 weight percentages of zirconium oxide nanoparticles. All the plates with acrylic block were immersed and incubated in artificial saliva containing Candida. Then samples were taken from the control solution and the one containing block. After analyzing the number of colonies, blocks were removed from the culture medium and their adhesion was analyzed in Sabouraud dextrose agar culture medium. One-way Analysis of Variance and post-hoc Tukey test were used to evaluate the inhibitory effect of zirconium oxide nanoparticles on Candida.

The growth of Candida albicans significantly decreased compared to that in the control group (p value < 0.001). The number of Candida albicans colonies adhered to the block in the control group was significantly higher than that in the two groups with 2.5 and 7.5 weight percentages of zirconia However, there was no significant difference between the two groups with 2.5 and 7.5 5 weight percentages of zirconia. Nanoparticles of zirconium oxide with 2.5 and 7.5 weight percentages can significantly reduce the growth and adhesion of Candida, and due to the toxicity effect, it is better to use the lowest weight percentage of nanoparticles.

Zirconium oxide nanoparticles of 2.5 and 7.5 weight percentages can cause a significant decrease in the growth and adhesion of Candida.