INVESTIGATING ANTIBACTERIAL EFFECT OF NEW MAGNETIC NANOPARTICLE AND [1,3]-DITHIINE DERIVATIVES AGAINST LACTOCOCCUS GARVIEAE

Loctococcus garvieae is a common bacterium between humans and animals, and it causes various diseases such as lactococcosis in aquatic animals. The [1,3]-Dithiine with two sulfur atoms in its structure is found in natural compounds such as garlic. Due to the antimicrobial activity of the [1,3]-Dithiine derivatives, and magnetic nanoparticles, in this study, antibacterial effects of the derivatives of this compound against Loctococcus garvieae were evaluated.

Six derivatives of [1,3]-Dithiine and a magnetic nanoparticles containing [1,3]-Dithiine were synthesized and antibacterial activity against Loctococcus garvieae were evaluated. Antimicrobial property was assessed using the CLSI (Clinical & Laboratory Standards Institut) standard and compared with gentamicin as a commercial drug.

Synthetic derivatives of [1,3]-Dithiine and magnetic nanoparticles showed acceptable antibacterial effects based on IZD (inhibition zone diameter), MIC (minimum inhibitory concentration), and MBC (minimum bactericidal concentration) with a range of 32-2048 μg/ml.

In the study of antibacterial activity, a direct and significant relationship between the structure of compounds and antibacterial activity was observed.