Assessment of The Effects of Nitrofurans on The Reproductive System in Adult Male Rats

5–nitrofuran is one of the several drugs studied for its role on reproductive system. In this study the effects of nitrofurans: nitrofurantoin, nitrofurazone, and furazolidone were analyzed. During a 50 – day period, adult male rats were given the drug via intrapritoneal injection. Thereafter male rats copulated with healthy females. The studied variables were the body weight, weight of tests and epididymis, hormonal assay, fertility and number of offspring. The results of this study showed no significant effects on the body weight and weight of tests and epididymis. Furthermore, a significant decreasing testosterone level was detected only in nitrofurazone and furazolidone treated groups. Also, fertility was not changed in any of the treated groups. Thus, short time exposure with these nitrofurans in low dose did ’nt affect fertility and only caused changes in levels of hormone.