Evaluation of endocrine abnormalities occurring during the follicular phase in women with recurrent spontaneous abortion

Recurrent spontaneous abortion (RSA) is a major problem in obstetrics and gynecology. Since today endocrinopathy is known to play a role in RSA, this prospective comparative study was conducted to determine endocrinologic abnormalities occurring during the follicular phase in women with RSA.

This study was conducted in Mirza Kochak Khan Hospital on a total of 108 women, 54 of who had RSA (study group) without any parental chromosomal rearrangement and 54 infertile women (control group) with tubal or male factor infertility without any history of abortion. The two groups were compared for concentration of hormones during their early follicular phases.

The means and standard deviations of ages were 27.55.1 in study and 28.15.6 in control groups without any significant difference. In the study group the mean serum prolactin was significantly higher than the control group (15.67.1 vs 123.9, p=0.002). The mean serum androstenedione in study and control groups were 1.90.7 and 1.30.4 respectively (P<0.001). Mean serum LH was 63.3 and 4.42 respectively (p=0.003). No significant differences between the two groups regarding means of FSH, TSH, Progesterone, 17-OH- progesterone, testosterone and estradiol were observed. In the study group the mean of BMI was significantly higher than in the control group (25.52.9 vs 22.61.7, p<0.001).

Recurrent spontaneous abortion is related to increased secretion of LH, prolactin and androstenedione in the follicular phase and BMI.