Comparing single- and multiple- dose prophylactic antibiotic in non complicated appendicitis wound infection

Post operative wound infections are among the most common causes of mortality and morbidity. Despite the introduction of new antibiotics in mid 20th century their widespread usage was resulted in resistant pathogens that grow and complicate wound infection management. In the present study, we have compared single- and multiple- dose prophylactic antibiotic in non-complicated appendicitis wound infection. 118 non-complicated cases of appendicitis had been enrolled for this randomized clinical trial. Their diagnosis was made according to their physical examination and laboratory findings. Patients were assigned in two groups, both of which received IV metronidazol (10mg/kg) and gentamicin (1.5mg/kg), preoperatively. For 58 patients postoperative antibiotic was discontinued (group A), however, 60 patients have continued their antibiotic regimen for 48 hours (group B). Patients were followed for 30 days. Wound infection was reported in 3.45% and 3.33% of the patients in the first and second group, respectively (NS). Results have revealed no significant difference between the two regimens.