Role of C - Reactive Protein in Prediction of Type 2 Diabetes: Tehran Lipid and Glucose Study

Several studies suggest that CRP plays a role in the pathogenesis of diabetes in adults. We tested the hypothesis that elevated levels of CRP at baseline can predict later onset of type 2 diabetes mellitus. In a nested case-control study, serum level of CRP was measured from stored samples of 73 control and 80 cases from among participants of the Tehran Lipid Glucose Study, who had been followed for 3.6 years. In age adjusted model, levels of CRP were associated with an increased risk of type2 diabetes, OR 3/6 (95%CI: 1.5 – 8.2) for tertile 3 versus 1, p.001. However in multivariate analysis the association between CRP and type 2 diabetes was significantly decreased after adjustment for fasting plasma glucose, body mass index, family history of diabetes, HOMA-IR, OR. 8 (95%CI:0.2 – 2.8) for tertile 3 versus 1, p 0.7. Elevated levels of CRP were associated with an increased risk of type 2 diabetes however, the association was not independent of other diabetes risk factors, including fasting plasma glucose, body mass index, HOMA-IR and family history of diabetes.