The Role of Serum Testosterone and Urinary Citrate on Urolithiasis

Aim was to study the influence of serum testosterone and urinary citrate on the formation of urinary stones in men and women, and to apply the findings for preventing urolithiasis.

We studied 200 patients (100 were men and 100 women) who had referred to the urology clinic at Imam Khomeini hospital and Seda Sima ESWL center. In both groups, 50 were stone formers and 50 were control group with no past history of urinary tract stones. The age range was between 17 and 60 years. All the tests were performed at one laboratory and SPSS 10 software was used to evaluate the results.

In men with history of urinary stone formation, the mean serum testosterone level was 9.99 ng/ml, with standard deviation of 6.6, and in control group it was 12.53 ng/ml ,with the standard deviation of 9.3 . In women, the stone formers had mean testosterone value of 1.01ng/ml with standard deviation of 1.6 , whereas in the controls, the mean value of serum testosterone was 1.14 ng/ml, with ST of 0.65. Regarding the 24 hours urinary citrate ,the mean value for men with stone formation was 95.5 mg/24 hrs and standard deviation of 89, while in the non stone formers , the mean level was148.6 mg/24 hrs with standard deviation of 119.the difference was significant ,which showed the preventive role of urinary citrate on stone formation. In women too, similar results were observed ,with mean levels of 106.2 and 142.1mg/24 hrs in stone formers and control group, respectively.

Statistically, no expressive differences were found between the two groups of stone formers and control group regarding serum testosterone levels ,but considering urinary citrate, it seems that a direct correlation exists between two groups ,both in men and women.