Investigating the Effect of High-Dose 99mTc-MIBI on Chromosomal Damage Induction among Patients Undergoing Myocardial Perfusion Scan

Considering progressively increasing number of myocardial perfusion scan using 99mTc -MIBI and the importance of probable cytogenetic effects yielded from administration of high dose 99mTc in this scan, this study was carried out on patients referred to nuclear medicine department of Taleghani hospital to investigate the effects of total dose of 40 mCi 99mTc on chromosomal damage induction. This clinical trial study was performed on 25 consecutive patients who were referred for myocardial perfusion scan, and signed written agreement to be involved in study. Patients’ Blood samples were assessed for chromosomal damage before and 48 hours after administration of 40 mCi 99mTc-MIBI, using micronucleus assay. The number of binucleated lymphocyte containing micronucleus and apoptotic cells were counted and compared by paired t-test. Among 25 patients (52% male) with mean age of 54.6±8 years old, the means of binucleated cells with micronucleus and apoptotic cells per 100 lymphocytes altered from 10.9±3.8 to 11.3±4.2 and 16.4±7.8 to 16.6±7 in secondary blood samples, respectively. It seems that myocardial perfusion scan does not induce chromosomal damage in Iranian race.