Relationship Between Hypertriglyceridemic Waist Phenotype with Metabolic Disorders in Individuals with Family History of Diabetes

Recent studies have used antropometric measures along with biochemical indicators as screening tools for chronic diseases. Few studies have assessed the relation of Enlarged Waist Elevated Triglycerdemic (EWET) phenotype with diabetes, particularly among individuals with family history of diabetes. This study aimed to evaluate the association of the EWET phenotype with diabetes among individuals with family history of diabetes. Antropometric and biochemical measurments were assessed in a pouplation-sbased cross-sectional study of 332 male and 991 female Isfahani adults, aged 35-55 years. The EWET phenotype was defined as serum trigcylglycerol concentrations ≥ 150 mg/dl and concurrent waist circumference ≥ 88 cm in women and ≥ 102 cm in men. The prevalence of the EWET phenotype was 9.6% among men and 23.6% among women. Individuals with the phenotype had significantly higher antropometric measurements as compared to other groups. After control for age and physical activity, men with the EWET phenotype were significantly more likely to have high serum cholestrol (P<0.001), systolic BP (P<0.01) and diastolic BP (P<0.001). Even after aditional control for BMI the significant associations remained except for low HDL Cholestrol women with the EWET phenotype, who had significantly adverse metabolic risks as compared to other phenotypes, both before or after control for BMI (P<0.001). Individuals with the EWET phenotype were more likely to have diabetes (both genders) and IGT (women only). Our findings showed a significant association between the EWET phenotype and diabetes. This phenotype could be used for early identification of diabetes and IGT.