Effects of Sesame Oil on Blood Glucose and Lipid Profile in Type II Diabetic Patients Referring to The Yazd Diabetes Research Center.

Type II Diabetes is one of the most prevalent endocrine diseases in the world that results from a combination of insulin resistance and ß-cell failure. Regarding importance of nutritional factors in management of diabetes, this study was designed to explore the effect of sesame oil on blood glucose and lipid profile in type II diabetic patients at Yazd Diabetes Research Center in 2007.

A quasi-experimental study was conducted on 25 patients with type II diabetes mellitus (age: 51.5±6.28y BMI:27.3±3kg/m2 disease duration:7.08±5.03y Fasting blood glucose level: 181±51.9mg/dl). Subjects received 30 g/day sesame oil for 6 weeks. Sesame oil was supplied to the patients, who were instructed to use it in place of other cooking oils for 42 days. Plasma glucose, glycated hemoglobin (HbA1c), lipid profiles [Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)] were measured at baseline and after 45 days of sesame oil substitution. 24 hours dietary recalls were obtained at the start , middle and end of study. Data was analyzed using analysis of variance with repeated measures and paired t-test.

Following 42 days intake of sesame oil, there were significant decrease in FBS (181±51.93 vs 154±39.65 mg/dl), HbA1c (9.64 ± 2 vs 8.4 ± 1.74 percent), TC (226.68 ± 31.4 vs 199.8 ± 37.87 mg/dl), LDL-c (123.9 ± 34.56 vs 95.53 ± 32.54 mg/dl) compared to pre-treatment values. (P <0.05) . Blood TG level decreased after intake of sesame oil but this difference was not significant (P=0.2).Also, the changes of HDL-c levels were not significant (P=0.1).

Sesame oil consumption results in considerable decrease in blood sugar, HbA1c and blood lipid levels (TC and LDL-C) in type II diabetics. Keywords: Sesame oil, FBS, HbA1c, TC, TG, LDL-c, HDL-c, Type II diabetes.