Leukocyte adhesion deficiency syndrome and report of three cases

ntroduction: Leukocyte adhesion deficiency syndrome (LADS) is a rare inherited immunodeficiency in which the function of leukocytes, particularly the phagocytes are disturbed. Case report: In the present sudy, we report three cases with LADS (2 male infants and 1 female child) who had a history of delay in separation of umbilical cord. One infant admitted for skin infection and two patients admitted in hospital following bacterial and fungal infections in nose and finger.All cases had a remarkable leukocytosis, neutrophilia and decreased of CD11 and CD18. LADS is a congenital syndrome causes recurrent bacterial and fungal infections. Usually all patients have a history of delayed separation of umbilical cord.