Determination of the acute and persistant effects of Aluminium on memory and learning abilities of rat

In regard to the role of Aluminium in the emergence of psychological disorders in patients with chronic kidney diseases, this research project studied the acute, and chronic effects of Alluminium on memory and learning abilities of rat. In order to determine the short and long term effects of Alluminium on different stages of memory and learning abilities, after grouping the rats Alluminium chloride with concentrations of 1mg, 5mg, 10mg and 20mg was used per kg of body weight. The Alluminium was given by intraperitoneal injection during 3 phases of 30 days, 60 days, and 90 days and following this a shuttle box was used to evaluate its effects on memory and learning abilities. The results indicated that plasma level of alluminium was significantly increased, however Alluminium at 90 mg/kg had no significant effect on the rat’s ability of learning. However doses of 1, 5, 10 mg/kg clearly had a significant inhibition effect on memory and learning abilities. This inhibitory effect had a direct correlation with the duration and does of the Alluminium injection. The highest inhibitory effect on memory and learning abilities was achieved at 15 mg/kg dose at 30 and 45 days, which was 34.5 and 52.3% respectively (P<0.05). Injection of 2 mg/kg of arecholine caused an increase of 25% in learning abilities and was statistically significant in comparison to the control group (P<0.05). It can be concluded from this study that Alluminium have an inhibitory effect on metabolism of nerve cells, and induces alterations on memory level and rat’s learning ability, these changes completely depended on the concentration and duration of exposure to Alluminium.