Study of glucose-6-phosphate dehydrogenese (G6PD) gene mutations in patients with G6PD deficiency of Fars and Esfahan provinces
Author(s):
Abstract:
Background
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, being present in more than 400 million people worldwide. The aim of this study was the molecular analysis of common G6PD mutations, including Mediterranean, Chatham, Cosenza and A-(G202A/A367G) in the patient with favism in Fars and Esfahan provinces. Materials And Methods
In this basic study, 96 non-relative patients with G6PD deficiency (34 from Fars and 62 from Esfahan province) were studied. Genomic DNA was analyzed by PCR-RFLP and product electrophoresis method for known mutations such as Mediterranean(C-T)nt, Chatham, Cosenza and A202(G-A)/367(A-G) mutation. Results
Of 96 samples, 79 (82.3%) and 8 (8.3%) had G6PD Mediterranean and G6PD Chatham, respectively. None of the samples had Cosenza and A-(G202A/A367G) mutation. Conclusion
This study showed that G6PD Mediterranean is the most prevalent mutation in Iran.Language:
Persian
Published:
Medical Science Journal of Islamic Azad Univesity Tehran Medical Branch, Volume:19 Issue: 4, 2010
Page:
280
magiran.com/p706296
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!