The Study of the Effect of Deprenyl on Gliosis after Spinal Cord Compression in Adult Rat

To study the effect of deprenyl on neuroprotective or survival on motoneuron and on gliosis reaction.

Sprague Dawley rats (250-300 gr) of Razi institution were used to determine the effect of deprenyl (2.50 mg/kg) on neuroprotective or survival on motoneuron and on gliosis reaction through morphometry and immunohistochemistry methods.

The results are divided into two parts:1- the result of morphometry for motoneuron.2- Astrocyte and oligodendrocyte count and their percentage. After spinal cord compression, motoneuron in ventral horn decreased with cavitation. While,the changes in study group (deprenyl) is less than control group(normal saline) one of the groups that had taken Deprenyl for 4 weeks revealed less changes so, after 4 weeks, the neuroprotective effects of Deprenyl increased (P≤ 0.05). In addition, Deprenyl had also decreased the gliosis reaction. It was even more effective after 4 weeks (P≤ 0.05).

For the first time, Deprenyl effect was studied in gliosis reaction. It seems that it decreased the number and percentage of astrocyte and became more effective after 4 weeks.By the way it needs more research to find the effect and mechanism of deprenyl in different dosage.