Therapeutic Effect of Vitamin B6 on Gastro-Intestinal Symptoms of Primary Dysmenorrhea in Young Women in Yazd City (2006-2009)

Dysmenorrhea is painful cramps which happen just before or at the start point of menstruation without organic reason, which is occasionally accompanied by gastro-intestinal problems. This study was performed in order to examine therapeutic effect of vitamin B6 on gastro-intestinal symptoms such as nausea and vomiting due to primary dysmenorrhea.Present study is a double blind case-control randomized study on girls aged between 11-17 years with primary dysmenorrhea who referred to gynecologic clinics of Shahid Sadoughi Yazd in years 2006-2008. 180 girls who had gastrointestinal symptoms accompanying dysmenorrhea selected and were divided into 2 groups: Vitamin B6 group (N: 90) who received 100mg vitamin B6 (two 50 mg capsules) daily in luteal phase for 3 months and placebo group (N: 90) who received two placebo capsules similar to vitamin B6 for 3 months. Data was analyzed by SPSS 11 using T-test and Chi-square test.Vitamin B6 reduced nausea of dysmenorrhea 82.2% and placebo effect was 40% (P= 0.001). Vomiting was reduced 64.4% in vitamin B6 group and 26.6% in placebo respectively (P=0.001). No drug side effect was seen in any of groups. Vitamin B6 can be use as an effective drug on gastro-intestinal symptoms of primary Dysmenorrhea.