Comparision of electrocardiogram changes and Na+, K+, Ca2+ and Mg2+ levels of serum and urine in bolus injection and continous infusion of furosemide in dog

Furosemide is a loop diuretic that with affecting on ascending part of henles tubule, increase urine volume. With attention to direct effect of furosemide on Na+, K+, Ca2+ and Mg2+ levels and cell functions (neuron, heart, muscle), itseems that the route of administration of furosemide, can influence the level of abovementhioned cations. When this drug can be effective that has minimum changes onelectrolyte levels. In this study we compare the bolus injection versus continues infusion of furosemide on electrocardiogram changes and Na+, K+, Ca2+ and Mg2+levels of serum and urine. In this study, sixtheen domestic male dogs were selected randomally and divided to two groups. In group 1, bolus injection of furosemide (6mg/kg)and in group 2, continous infusion of furosemide with samedose were administrated.