Thyroid Autoimmune Markers in Patients with Hypothyroidism

Background and Thyroid autoimmune disease is the most common thyroid disorder in low-iodine intake areas; evaluation of thyroid peroxidase antibodies (TPOAb), anti-Thyoglubolin (TGAb) and anti-microsomal (TMAb) in most patients with hypothyroidism is of significant importance. Therefore, the present study was conducted to determine the role of anti-thyroid antibodies in patients with hypothyroidism in Sabzevar, Iran. Methods and Materials: This is a cross-sectional descriptive analytical study where 382 subjects with TSH above normal and T3 and T4 below normal were selected through non-probability convenient sampling. Their TSH, TPOAb, TGAb and TMSb were measured through Eliza method. The obtained data were analyzed in SPSS 15 using chi-square, independent t-test and Pearson correlation coefficient, where P<0.05 was considered significant. TPOAb, TGAb and TMSb in men and women with TSH higher than 10 mIU/ml were 72.3%, 78.3% and 50% positive respectively. In 72.3% of the subjects, TPOAb was above normal; in 78.5% of them TMAb was higher, and in 50% of them TGAb was higher. The highest rate of correlation was observed between TGAb and TPOAb (r=0.89). The results indicated that, in the population studied, TPOAb, TMAb and TGAb were higher than the normal rates, and that TPOAb and TGAb are more remarkably changing to higher rates than TMAb.