Investigation of anti-convulsant effect of alcoholic Ferula Assa Foetida gum extract PTZ-induced kindling model in mice

Regarding the prevalence of epilepsy in human society and with respect to insufficiency of used treatment, the new strategy and methods for medical treatment of epileptic patients are necessary. Ferula assa foethica (F.foethica) is an important species of medicinal plant that has been used in traditional medicine as an anticonvulsant herb. So the present study has investigated anti-convulsioneffect of F.foethica gum extract using PTZ-induced kindling method.

In the present study, 60 balb/c male mice were randomly selected and divided into 6 experimental groups (n = 10 in each group), i.e. 1. control, 2. PTZ, 3, 4 and 5. treatment groups which received the extract in 25, 50 and 100 mg/kg; i.p, respectively, and 6. positive control group which received VA (100 mg/kg) as an anticonvulsant drug. All groups were kindled by 11 period injection of PTZ(35 mg/kg; i.p.). In the 12th injection, all groups were tested for PTZ challenge dose (75 mg/kg). However, exhibited phase of seizure (0-5) were observed and noted till 30 min after PTZ injection.

Our data showed that the F. foetida gum extract has a reduction effect on seizure intensity, progression, and duration.

The attained results showed that hydro-alcoholic gum extract of F. foetida can be used in grand male seizure treatment.