The effect of intracerebroventricular injection of CNQXin cumulative food and water intake in chicken

Aim and Background. Previous researches about physiological mechanisms of appetite control in mammalian and avian indicated central and peripheral agents. Glutamate as one of the mostimportant neurotransmitter has a significant role in central and peripheral control of appetite and someglutamatergic circuits involved in control of appetite. Intracerebro ventricular (icv) injection of glutamateand its agonists leads to severe decrease of foodintake. Ionotropic receptors of glutamate include NMDA andnon-NMDA (AMPA and kainate) receptors. This study examines effects of Interacerebroventricular injectionof CNQX as a Non-NMDA receptor anatagonist in cumulative food and water intake in chicken.Materials and Methods. When chickens received 700-750 gram, after general anesthesia and aseptic surgerycanula replaced in lateral ventricule. This study performed in four group, one control and three treatments. There were 9 birds in any group. After injection of different doses of drug, cumulative food andwater intake measured in 15, 30, 60, 120 and 180 minutes.Results.Interacerebroventricular (icv) injection of CNQX increased cumulative food intake (P<0.05) dosedependently, as compared with control group and injection of CNQX decreased water intake (P<0.05) dosedependently.Conclusion. According to these results Non NMDA receptors (AMPA and Kainate receptors) have important role in decreasing food intake dose dependently and also these receptors have important role in cumulative water intake in chicken.