Haseman-Elston Regression Methods in Genetic Linkage Analysis

One of the important problems that bring up in genetic fields is determining of loci of special gene in order to gene mapping and generating more effective drugs in medicine. Genetic linkage analysis is one important stage in this way. Haseman-Elston method is a quantitative statistical method that is used by biostatisticians and geneticists for genetic linkage analysis. The original Haseman-Elston method is presented in the year 1972 and ever after many investigators recommended some suggestions to make better it. In this article, we introduce the Haseman-Elston regression method and its extensions through 1972 to 2009. and finally we show performance of these methods in a practical example.