Effect of short-term garlic extract supplementation on oxidative stress and inflammatory indices in non-athlete men after an aerobic exercise

The aim of this study was to determining effect of short-term garlic extract supplementation on serum total antioxidant capacity(TAC), malondialdehyde and and total peripheral leukocytes counts in non-athlete men after an aerobic exercise. Twenty non-athlete men (aged 23±3 years, body fat 16±2%, and VO2max 40±3 ml/kg/min) in a randomized and double-blind design were divided in two equal groups: supplement group (garlic extract, 700mg/day) and placebo group (dextrose, 700mg/day). After supplementation period, all subjects were participated in aerobic exercise protocol with75% VO2max on the treadmill for 30 minutes. Primary blood samples in the basic state and before of start supplementation, second blood samples after the end of supplementation period and third blood samples after the exercise were taken. Data were analyzed by repeated measure ANOVA, Bonferroni and independent t test using SPSS at α≤0.05. Show that short-term garlic extract supplementation had significant effect (P<0.05) on basal serum TAC. Moreover, MDA, total peripheral leukocytes counts was significantly increased and TAC was significantly decreased (P<0.05) after 30 min aerobic exercise. The change range in the oxidative and inflammatory indices of placebo group, However, was significantly more than in supplement group (P<0.05). Our results suggest that the increase of resting total antioxidative capacity following Garlic short supplementation can cause decrease exercise-induced oxidative damages (Lipid Peroxidation) and inflammatory indices (Leukocytosis) in non-athlete men.