Comparative Study on Xnograft Saffold and Prous Hydroxyapatite/Tricalcium Phosphate for the Repair of Bony Defect

The aim of this study was to compare xenograft scaffold and prous Hydroxyapatite/ Tricalcium phosphate for the repair of bony defect. 5 New Zealand rabbits with the average weight of 2 kg were used. The rabbits were anesthetized with ketamine 60 mg/kg and xylazin 6 mg/kg After creating a critical-sized segmental defect (2×3 cm) in tibia bones, an implant of HA/TCP with osteoblasts in the hole of left tibia and an implant of xenograft with osteoblasts in the hole of right tibia was inserted. At the end of the second month, the animals were sacrificed. To follow up the new bone formation, x-ray images were taken at 8th week post-operation. To confirm the tissue repairment, the histology of repaired defects was evaluated with H&E staining after decalcification. The present study demonstrates that the critical-size segmental defect of tibia can be repaired with both synthetic HA/TCP and xenograft implants. xenograft implants showed better osteointegration compared to HA/TCP phosphate.