Is Ovarian Mass Malignancy Prediction Accuracy Increased by Adding Serum CA125 Measurement to Sonographic Findings?

Introduction & The aim of the present study is to determine the accuracy of malignancy prediction in adnexal mass if CA125 measurement is added to sonographic findings. In a cross sectional study, AUC of ROC Curve of malignancy prediction based on sonographic findings in comparison to a new model (OMPS2) based on sonography plus serum CA125 was calculated. Pathologic reports of 430 operated adnexal masses were included in the study. Logistic regression analysis was used. New model (OMPS2) was constructed as follow: OMPS1+1.444(if CA125=36-200) or 3.842 (if CA125 is above 200).AUC of ROC curve of malignancy prediction increased from 78.1% (based on OMPS1) to 84.3% (in OMPS2). Serum CA125 measurement in addition to sonography increased the accuracy of malignancy prediction in comparison to only sonography.