The effect of electrode site on auditory P300 in normal subjects

Event related potentials can be considered as a valuable tool for understanding cortical functions. P300 can be affected by a number of factors including the site at which electrodes are to be placed. This study was conducted to compare the amplitude and latency of P300 across different electrode sites in normal individuals aged between 18 to 50 years In this cross-sectional non-interventional study, an oddball paradigm was adopted to compare P300 event-related potential through using two tone burst stimuli in 27 normal cases with average age of 23.2 years. Obtained data were statistically analyzed via paired t-test using SPSS software (version 16). Significant differences were shown in mean latency and amplitude of participants’ P300s recorded at different electrode sites (P < 0.05). According to results of this study, active electrode site is effectual in recording P300. Posterior electrode site is recommended for enhanced recording of P300.