Relationship between -5T/C polymorphism of platelet GP1BA gene promoter and premature acute myocardial infarction in patients referred to Rajaee Heart Center

Background and ObjectivesSome platelet membrane glycoprotein gene polymorphisms have been reported as potential factors related to cardiovascular complications. Recently, the -5T/C polymorphism located at the initiation element (Kozak sequence) of the platelet glycoprotein Ibα (GPIbα) translation was suggested to increase the platelet surface levels of GPIb-IX-V receptor; however, its function in the occurrence of arterial thrombotic disease is unknown. In this study, we evaluated the role of the GP Ibα -5T/C polymorphism in premature myocardial infraction among Iranian patients. Materials and MethodsTwo hundred subjects who underwent coronary angiography were studied on the basis of the study protocol through 2010. Patients (n=100) selected by WHO criteria and matched on age parameter with controls (n=100; Men <50 years old and Women < 55 years old). The genotype distribution of GP Ibα -5T/C polymorphism was evaluated by PCR-RLFP technique. ResultsThere were no significant differences in age, hypertension, and diabetes between the patients and controls. However, the sex, family history of CAD, smoking and hyperlipidemia had a significant difference between the two groups. The allele frequencies of C and T were calculated to be 0.13 and 0.87, respectively. In addition, the CC genotype showed to be a potential factor for the occurrence of myocardial infarction (p=0.56, OR = 3.06, CI(95%) = 0.31-29.94). ConclusionsAlthough no significant association was observed between the - 5C/T polymorphism and premature myocardial infraction, we considered that the C allele may be an effective factor for premature myocardial infraction.