The Effect of Oral Magnesium Sulfate on the Level of Pituitary-Thyroid Axis Hormones (TSH, T3, T4) in Rat

Background and Magnesium is a unique element among the trace elements, because it plays a role in a vast range of metabolic processes such as carbohydrate, lipid, protein, and the integrity of nucleic acids. Noting the role of this element in the physiological activity of organelles and tissues and the importance of the regulation of thyroid hormone levels in the body, this study considered the effect of esculent magnesium sulfate on the values of TSH, T3, and T4 hormones.Methods and Material: In this experimental study, 40 adult male Wistar rats weighing nearly 190-200 g were used. The rats were divided into five groups of eight: the experimental groups received 2, 4, and 8 molars of edible magnesium sulfate solution, respectively, while the control group received nothing. The sham group received only distilled water. The prescription was continued for 28 days and bleeding the heart was done to measure the mentioned factors of the serum. The mean concentration of the hormones was analyzed using suitable statistical methods, such as ANOVA and Tukey’s test, and compared between the control and experimental groups. The statistical analysis showed that the concentrations of TSH, T3, and T4 hormones increased significantly after receiving the different values of magnesium sulfate compared with the control group (p < 0.05). Based on the results of this investigation, magnesium sulfate in the last 28 days increased the thyroid activity leading to increased serum levels of TSH, T3, and T4 hormones.