مجله دانشگاه علوم پزشکی قم
سال نهم شماره 8 (پیاپی 43، آبان 1394)

Reduction in blood circulation and oxygen delivery can affect structure and function of testicular tissue and spermatogenesis. The present study was conducted to evaluate the protective effect of vitamin C and royal jelly coadministration on the experimental hemolytic anemia-induced changes in testicular histoarchitecture in adult mice. In this experimental study, 32 adult mice weighing 20-25g were divided into 4 groups, including control group that received normal saline (0.1mL, IP), sham-control group received phenylhydrazine (PHZ) (6mg/100, IP), PHZ+vitamin C (250mg/kg, IP)+royal jelly (100mg/kg, orally) group, and royal jelly+vitamin C group. Following the 35-day treatment period, the tissue samples were dissected out. After tissue passage, embedding, and section preparation, the slides underwent hematoxylin and eosin staining. Different parameters, such as testis capsular thickness, germinal epithelium height, seminiferous tubules diameter, number of seminiferous tubules per 1 mm2, mean number of primary spermatocytes, Leydig cells, active Sertoli cells, and mast cells, were assessed. Observations revealed a significant reduction in the evaluated parameters in the PHZ group, which this reduction was prevented by coadministration of royal jelly and vitamin C as an antioxidant. The results of this study indicated that coadministration of vitamin C and royal jelly was able to neutralize the detrimental effect of hemolytic anemia on the reproductive system of laboratory mice.

Essential fatty acids, such as α-linolenic acid (ALA), as an omega-3 fatty acid, and linoleic acid (LA), as an omega-6 fatty acid cannot be synthesized by human cells. Therefore, they should be provided from food sources, such as fish, soybean oil, flaxseed, and sunflower seeds. The process of α-linolenic acid synthesis is performed by 6 enzymes, one of which is stearoyl-acyl-carrier-protein-desaturase (S-ACP-DES). This study was carried out aiming at designing prediction models to determine the structure of stearoyl-acyl carrier protein desaturase 1. Some bioinformatics tools were used to determine the most important gene features of S-ACP-DES enzyme in order to develop some organism prediction models. Then, data mining techniques, such as feature selection, decision tree, and classification models, were used to develop efficient and accurate prediction algorithms based on gene features of enzyme (S-ACP-DES) from various organisms. The most important gene feature in the identification of organism structures of the enzyme (S-ACP-DES) was frequency of length. Also, the designed prediction models indicated that Naive Bayes model with FCdb criteria and accuracy of 97.83% can predict new organism enzymes based on the gene features. The above findings have been reported for the first time in this study. The results of this study showed that with the use of bioinformatics tools, we can classify DESA1 enzyme based on its organism, and the variable of the length of genes is the best indicator for this classification. Also, the best learning machine model in Naive Bayes was Bayesian with high accuracy of 38.97% for determination of DESA1 enzyme, which has been reported for the first time in this study.

Backgrounds and The effect of honey or vinegar has been studied separately on metabolic abnormalities. The mixture of these two ingredients as honey vinegar, in combination with water, is one of the Iranian's traditional syrups. Considering the therapeutic effect of honey vinegar on blood pressure, no study has yet been carried out in this regard. The aim of this study was to assess the effect of the consumption of honey vinegar syrup on blood pressure and anthropometric indices in healthy individuals. This clinical trial was conducted as a randomized, controlled, and parallel study during a 4-week period. A total of 72 non-obese healthy volunteers were selected, and randomly assigned to two groups of intervention and control (36 subjects in each group). All subjects were asked to remain on their normal diet. The intervention group received daily a glass of honey vinegar syrup as snack (evening meal) (250ml syrup containing 21.7g honey vinegar). Assessment of blood pressure and anthropometric indices was performed before and after the intervention. Data were analyzed using paired t-, independent t-, and covariance statistical tests. The significance level was considered p<0.05. In this study, honey vinegar syrup had no significant effect on blood pressure and anthropometric indices. The results showed that honey vinegar syrup in the received doses, had no significant effect on anthropometric indices and blood pressure. Therefore, further researches are necessary to confirm or refute the claim of the ineffectiveness of this syrup on anthropometric indices and blood pressure.

Somatization is a somatoform disorder, which medical examinations are not able to explain its reason. This study was conducted with the purpose of clarifying the role of personal traits and alexithymia in somatization disorder. The present research was performed as a descriptive correlational study. In this investigation, 350 subjects were selected through stratified random sampling method. In the current study, NEO Personality Inventory-revised (NEO PI-R), somatization PHQ-15 questionnaire, and Toronto Alexithymia Scale-20 were used. Data were analyzed using simultaneous regression analysis. In this study, there was a significant negative relationship between somatization and five factors of extraversion. Also, neuroticism and alexithymia had significant positive relationships with somatization. There wasnot any relationship between openness to experience and personality traits. The results of the present study indicated that with strengthening individual's social relationships and training the methods of expressing feelings, steps can be taken towards preventing somatization.

Cardiovascular diseases are one of the most common causes of mortality worldwide. The aim of this study was to investigate the effect of cardiac rehabilitation on the results of 6-minute walk test after angioplasty. This study was an analytical cross-sectional study conducted on 96 patients who had undergone angioplasty in Shahid Beheshti Hospital of Qom City, 2014. Half of the patients who underwent cardiac rehabilitation 3 times a week for 8 weeks, were placed in the case group and the remaining were placed in the control group. Demographic data and the results of the 6-minute walk test of all the patients were obtained before and after rehabilitation in the case group and 2 weeks and 10 weeks after the operation in the control group. Assessment and comparison of the variables were performed using Chi-square, independent t-, and paired t-tests. Significance level was considered less than 0.05. The mean age of the subjects in the case group was 57.21±9.09 years and in the control group was 57.03±10.89 years, and 70.8% of the patients were male and the remaining were female. A significant difference was observed between the case and control groups in terms of the distance walked in the 6-minute test, before and after cardiac rehabilitation (p<0.001). On the other hand, comparing the distance walked between the two groups, was indicative of a significant difference between the two groups (p<0.002). Cardiac rehabilitation after angioplasty is an appropriate method for increasing functional capacity of patients, therefore it is recommended that all the patients be referred to physiotherapy and cardiac rehabilitation ward.

Vitamin D deficiency is considered a risk factor for many chronic diseases such as Type 2 diabetes mellitus (T2DM). Considering the role of vitamin D in incidence and prevalence of diabetes and the widespread prevalence of vitamin D deficiency in Iran, the present study was conducted with the purpose of assessing the serum level of vitamin D with glycemic and anthropometric indices in diabetic patients. In this descriptive cross-sectional study, 84 T2DM patients were selected. Anthropometric indices [weight, height, waist circumference, hip circumference, BMI, waist-hip ratio (WHR)] and Biochemical parameters (fasting serum glucose, HbA1C, fasting insulin, 25(OH) vitamin D, and insulin resistance index) were measured. The participants were divided based on the serum level of vitamin D into three tertiles of severe deficiency (0-10ng/ml), moderate deficiency (10-20ng/ml), and insufficiency (20-30ng/ml). Data were analyzed using Chi-square, independent t-, ANOVA, and Pearson tests. The level of significance was considered at p<0.05. The serum level of 25(OH) D in females was significantly lower than males (p<0.05). A significant relationship was observed between fasting blood sugar level, WHR, and vitamin D, but the relationship between vitamin D and other factors (Insulin, HbA1C, and HOMA-IR) and anthropometric parameters, was not statistically significant. In the present study, due to the negative correlation between vitamin D level and fasting blood sugar, which is indicative of indirect effect of vitamin D on insulin secretion, and also high prevalence of vitamin D deficiency in diabetic patients, it can be concluded that hypovitaminosis D has a negative effect on glucose homeostasis.

Activities of daily living are the most fundamental components of life, and reflect an important aspect of functional independence in older adults, which declins with increasing age. This research was performed with the purpose of predicting activities of daily living in the older adults in Qom City based on fall-related psychological factors. In this descriptive correlational study, 340 older adults were selected by convenience sampling from urban areas of Qom City. Data collection was carried out using demographic characteristics questionnaire, Activities of Daily Living Scale of Khajavi & Parsa, Yardley et al.’s Fall Efficacy Scale-International, Activities-specific Balance Confidence of Myers et al, and modified Gait Efficacy Scale of Newell et al. Data were analyzed by descriptive statistics, Pearson’s correlation coefficient, and regression analysis. The significance level was considered to be p≤0.05. In this study, the mean age of participants was 70.80 years. There were a significant relationship between activities of daily living and fall-related psychological factors in the older adults in Qom City (p≤0.05). Activities of daily living were significantly predicted by variables, including gait efficacy, fear of falling, and balance confidence. These predictor variables explained 93% of variability in activities of daily living (r2=0.93, f=681.307, p≤0.000). According to the results of this study, fall-related psychological factors by affecting older adults’ self-perceptions can decrease self-efficacy in performing activities of daily living. Also, these factors can be considered in interventions targeting improvement in activities of daily living. Therefore, future studies are necessary to investigate older adults’ functional performance based on the fall-related psychological factors.

Nowadays, there is an increasing emphasis on workplace mental health promotion. On the other hand, mental disorders can effectively change individuals and their job. This study was conducted with the aim of assessment and comparison of workers’ mental health and its components among different industries in Qom Province. This study was performed as a descriptive cross-sectional study on the mental health level in workers of industries in Qom province, 2014-2015. Information were collected from 379 workers (seven industries of Qom Province). The study tools were demographic questionnaire and Goldberg’s General Health Questionnaire-28 (GHQ-28). Data were analyzed using t-test, one-way ANOVA, and Pearson’s correlation statistical tests. In this investigation, the age of the workers ranged from16-62 years with the mean of 33.58±10.06 years. Social dysfunction and depression symptoms, respectively had the highest (5.97) and lowest (2.42) mean scores. The score of GHQ score was 17.78±9.84. Of these subjects, 30.4% were in undesirable condition in anxiety and sleep disorders, and 40.2% in social function. Also, There was a significant difference between single and married workers in terms of subclasses of general health psychological distress (p<0.05). Furthermore, the correlation between GHQ-28 subscales and total scale was satisfactory and ranged between 0.59 and 0.86 (p<0.05(. According to the results of this study, although overall level of general health subscales of the worker was not at undesirable level, the findings showed mental disorders among the workers.