مجله دانشگاه علوم پزشکی شهید صدوقی یزد
سال بیست و نهم شماره 5 (پیاپی 177، امرداد 1400)

Emergency school closures are often used as public health interventions during infectious disease outbreaks to minimize the spread of infection. However, Over 80% of children in the world have had their education impacted by coronavirus. For children with special needs who receive special education services, access to face-to-face education and other resources at school is of particular importance. These services focus not only on academic achievement, but also on social, emotional, psychological and physical health and well-being. The American Academy of Pediatrics advocates for students to attend school in person. Students with special needs are divided into seven educational groups: hearing impairment, visual impairment, physical-motor disorders, intellectual disabilities, behavioral-emotional disorders, autism spectrum disorder, specific learning disorder, and severe and multiple disabilities. Each of these groups should have a different way of teaching and learning than other groups and normal students. For proper planning and accommodation of children with special needs, we must prioritize safety. In order for these students to be able to use rehabilitation services, face-to-face education conditions must be provided for them in accordance with health protocols.

Epigenetic mechanisms regulate expression of the genome to generate various cell types during development or coordinate cellular responses to external stimulus. While epigenetics is of fundamental importance in eukaryotes, it plays a different role in bacteria. This article uncovers the most important recent data on how bacteria can alter epigenetic marks and can also contribute to and/or result to various diseases.In this review article, Sciencedirect, PubMed, Scopus, Google Scholar databases were used for finding the relevant studies.Research has shown that bacteria can affect the chromatin structure and transcriptional program of host cells by influencing diverse epigenetic factors (i.e., histone modifications, DNA methylation, chromatin-associated complexes, and RNA splicing factors). Therefore, bacterial-induced epigenetic deregulations may affect host cell function either to host defense or to allow pathogen persistence. Hence, pathogenic bacteria can be considered as potential epimutagens able to reshape the epigenome that their effects might leading to cellular dysfunctions, which influenced immunity and might be at the origin of unexplained diseases and this caused presentation or contributed to the development of pathological changes.

Epigenetic modifications during development and in response to environmental factors contribute to phenotypic variability and susceptibility to a number of diseases, including infectious diseases, cancers, metabolic and autoimmune disorders.

As a person gets older, their gait patterns change and their ability to walk decreases. Orthoses are used to relieve musculoskeletal disorders, skeletal problems, disabilities, etc. Therefore, the aim of this study was to investigate the effect of orthoses on timing of lower limb muscles in the older adults during gait.

The present study was a clinical trial. 14 females (with average age of 60.50±4.40 years) and 14 males (with average age of 63.35±5.55 years) were selected with available sampling, voluntarily participated in this research. Eight electrodes were placed on the selected muscles (tibialis anterior, gastrocnemius medial, vastus medialis, vastus lateralis, biceps femoris, semitendinosus, gluteus medius, erector spinae) to record electrical activity during the gait with and without orthoses. To analyze the data SPSS software (version 16), and a repeated analysis of variance test was used. The significance levels in all tests were considered to be 0.05.

The main effects of orthoses and the interaction effects of orthoses and sex for the onset of selected muscles activities did not show any significant differences (P>0.05). The effect of sex for the onset of activities in medial gastrocnemius (P=0.007), vastus medialis (P=0.002), vastus lateralis (P=0.027), semitendinosus (P=0.004), gluteus medius (P=0.030), and erector spinae (P=0.039) muscles was significant, so that the onset of muscle activity in the female group was earlier than in the male group.

Orthoses showed no improvement on onset of selected muscles activities, although significant differences were observed between the male and female groups.

Given the importance of the scale of difficulty in emotion regulation, in measuring the ability to regulate emotion in adolescents and adults, which is widely used in research and clinical settings, the purpose of this study was to investigate the psychometric properties of short form of difficulty in emotion regulation (DERS-16) in group of Iranian adolescents.

The method of  the present study was a survey in which the statistical population consisted of all 16 to 18 years old male secondary school students in Ardabil City in the 2019-2020 academic year (N = 21756). Among which 409 individuals were selected by cluster random sampling and individually responded to the DERS-16 & NEO-FF-R. To analyze the data internal consistency coefficient, divergent validity and exploratory and confirmatory factor analysis were used. Data were analyzed using SPSS version 16  and LISREL 8.8 software.

The results of internal coefficient showed that this scale had a good reliability. Fit indices of confirmatory factor analysis also showed appropriate scale validity (CFI = 0.99, RFI = 0.98, NNFI = 0.99, and RMSEA = 0.048).

Findings indicate that the Persian version of this scale is a good tool for measuring the difficulty in regulating emotion and can be used to assess the difficulty in regulating emotion in adolescents and adults.

Preeclampsia is described as a systemic disorder and leads to a potentially life threatening disease. The evidences show that stress oxidative of lipid profile is effective in the pathogenesis of Preeclampsia. In this study, specificity and sensitivity of lipid profile as a predictive factor in the incidence of preeclampsia was studied.

This study was a cohort study that conducted on pregnant women referring to hospitals from 2016 to 2017. In this study, 244 prim gravid women with normal blood pressure in the weeks of 16-18 were included and a lipid profile test wasrequested. Finally, it was followed the cases for the incidence of preeclampsia till the end of pregnancy. In this study, the SPSS 16 software was utilized. Moreover, the Chi-Square, Covariance and independent t tests was run.

During this study, 16 cases developed preeclampsia. In preeclamptic cases it was found considerable changes in lipid profile such as significant increase in LDL and TC, and significant decrease in HDL (P-value < 0.001). Likewise, it was not found considerable changes in TG (P-value=0.21). Furthermore, TC with sensitivity of 68.8 % and specificity of 69.6 %, LDL with sensitivity 75 % and specificity of 75.8 % and HDL with sensitivity of 76.2 % and specificity of 75 % were reported.

The findings in our study suggested that cases that developed preeclampsia had disturbed lipid profile and the best predictive factors are HDL, LDL and TC, respectively.

The purpose of this study was to describe the clinicopathologic features of lip lesions for early diagnosis and suitable treatment of  patients.

This was a  descriptive cross-sectional study on158 patients with lip lesions whose information was recorded in the Department of Pathology of Shahid Sadoughi Hospital from 2008-2012. Then the data were analyzed bySPSS software ver. 16, Chi- Square and Fisher’s Exact Test. In this study p-value was considered significant (P<0.05).

This study was performed on 158 cases (77 male and 81 female) with age ranged of 4-93 years. From those, 44 had malignant and 114 had benign lesions. The most common malignancy in this study was squamous cell carcinoma (SCC) and basal cell carcinomas (BCC), respectively. In benign lesions reactive ones, benign tumors and inflammatory lesions were more common, respectively.

The most common lip lesions were generally benign tumors, involving the lower lip. In addition, the incidence of malignant lesions was directly related to aging. For this purpose,  in any elderly person with a lip lesion, specially squamous cell carcinoma, must first be ruled out.

Concerns have been raised about the toxic effects of medicinal plants due to their increased consumption. Therefore, the aim of the present study was to investigate the hepatotoxic effects of aqueous extract of valerian in laboratory mice.

After preparation of plant materials and aqueous extract of valerian, concentrations of 10 and 20 mg/kg body weight were administered to laboratory mice for 14 days. On the day 14th, blood samples were taken from the hearts of mice after anesthesia and the serum levels of the enzymes alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) were studied. Furthermore, the animalschr('39') weight was recorded at 0, 7 and 14 days and weight changes were also studied.

The results of the present study showed the concentration-dependent effects of aqueous extract of valerian on increasing serum levels of liver enzymes such as ALT, AST, ALP and GGT and the highest serum levels of these enzymes were observed at a concentration of 20 mg/kg. Moreover, the concentration of 20 mg/kg aqueous extract of valerian caused severe weight loss in mice over a period of 14 days.

In general, it was concluded that a concentration of 20 mg/kg causes liver damage. However, low concentrations of 10 mg/kg valerian extract showed no toxic effects on the liver. Therefore, in the formulations prepared from valerian, attention to the concentration of the extract is very important and the use of lower concentrations to prevent hepatotoxicity is very important.

Congenital heart disease is the most common congenital anomaly. About 50% of Neonates with congenital heart disease are asymptomatic in the first few days of life and are not diagnosed on initial examination. Pulse oximetry is a non-invasive method that can show the percentage of oxygen saturation in the blood and congenital heart disease.

This was a descriptive cross-sectional study and the sampling method was census. Echocardiography was performed for all neonates with spo2 less than 95% and also neonates who were diagnosed with a problem by a cardiologist. After collecting the samples, the results obtained from pulse oximetry, physical examination and echocardiography were analyzed using SPSS software version 16 and statistical tests of Kolmogorov-Smirnov normality and Spearman correlation. Was investigated.

In pulse oximetry evaluation, 1.9% of neonates had spo2 (arterial oxygen saturation) less than 95%. 1.7% of neonates had heart problems in physical examination and 2.12% of neonates had heart problems in echocardiography. The highest correlation between pulse oximetry and echocardiography was 0.917.

Considering the diagnostic importance of congenital heart diseases and their impact on a personchr('39')s life, it is recommended that pulse oximetry be added to physical examinations at birth as a screening method for heart disease.