فصلنامه پوست و زیبایی
سال چهاردهم شماره 1 (پیاپی 53، بهار 1402)

Lower limb telangiectasias are commonly seen in the general population and especially in females. This disorder not only causes cosmetic problems but also can cause pain and related problems of increased venous blood pressure. These varicose veins are one of the most common causes that patients refer to dermatology clinics. Considering some complications and limitations of sclerotherapy, we decided to investigate the efficacy and safety of the Long-Pulsed Nd:YAG 1064-nm laser as an alternative method.

29 patients underwent at least three sessions of 1064 nm Nd: YAG laser treatment at intervals of 4 weeks. Before the first treatment session, after each session, and six months after the last session, photos were taken of the treatment site. Finally, clinical response and satisfaction rate with the treatment were recorded based on the score of a secondary dermatologist and the patient himself based on the improvement criteria from 0 to 4.

According to the dermatologist's judgment, the average satisfaction with the treatment is 3.38 out of 4 with a standard deviation of 0.5, and based on the patient's assessment, it is 3.2 out of 4 with a standard deviation of 0.71, which is equivalent to more than 76% of the effectiveness of Nd:YAG 1064 nm laser in the treatment of telangiectatic veins. The pain during laser treatment was recorded as 6.27 with a standard deviation of 2.64 based on The VAS Scale.

Our experience has demonstrated that the long-pulsed 1064 nm Nd:YAG laser is an effective, reliable, safe method in the treatment of telangiectatic and reticular veins of the lower limbs with minimal side effects and complications.

Genital wart disease is an infectious disease caused by a type of human papilloma virus that is transmitted through direct contact with the skin of people and mainly as a result of sexual intercourse. Therefore, the profile of psychological vulnerability in people with genital warts and its role in the level of impulsivity It was studied in patients at Razi Hospital.

The current research was of a descriptive-correlation type. The statistical population of the research consisted of all the people referred to Razi Hospital who were suffering from genital warts. 122 people were selected and included in the study. Psychological vulnerability questionnaire and Barat impulsivity questionnaire were used in this research. Data analysis was done with analysis of variance and independent t test, Pearson correlation and stepwise regression and SPSS 18 software.

The results showed that psychological vulnerability is normal in people with genital warts. Psychological vulnerability plays a role in impulsivity. Paranoid thoughts have an effect coefficient of 0.3030 and a prediction of 0.30.

Considering the role of psychological vulnerability in the formation of behavioral disorders such as impulsivity on the one hand and the role of impulsivity in contracting genital warts on the other hand, this research has practical implications in highlighting the areas of prevention and treatment of impulsivity.

Candida albicans have the ability to colonize living and non-living surfaces and form biofilms that are very resistant to common antifungals. The present study was designed to evaluate the fungicidal activity of itraconazole on Candida albicans biofilm.

The present study was conducted on 10 nail samples. Routine mycological and molecular tests were performed to identify and determine the type of fungus. Biofilm was formed in the 96-well plate and was subjected to the itraconazole. ROS accumulation was measured. ROS levels were determined in biofilms treated with itraconazole in the presence of antioxidants.The minimum inhibitory concentration of itraconazole was measured in the presence of ascorbic acid (10 mM) according to the protocol of the previous step. Annexin V-FITC apoptosis detection kit was used to investigate the possibility of apoptosis induction following itraconazole use. 

Mann-Whitney showed a significant difference between biofilms treated with itraconazole and untreated biofilms for 10 tested strains. Treatment with itraconazole resulted in a significant reduction in the number of biofilms. Ascorbic acid significantly reduced ROS accumulation caused by itraconazole for biofilms of all Candida albicans strains. The findings show that itraconazole induces ROS-dependent apoptosis in a dose-dependent manner in biofilm cells.

In this study, it was found that the presence of intracellular ROS is the main cause of the apoptosis mechanism of itraconazole. The ability of itraconazole to induce ROS in Candida cells appears to be a very effective fungicidal strategy.

The purpose of this research was to compare the effectiveness of cognitive behavioral and emotion-focused group therapy on reducing the symptoms of psoriasis, psychological distress and perception of body image.

This was a semi-experimental research of pretest posttest type with a control group. The statistical population of this research included all patients who were diagnosed with psoriasis in spring of 2022 by referring to dermatologists in Mashhad. 45 psoriasis patients were selected by available sampling method and replaced randomly in two experimental groups (CBT and EFT) and control group (each groups 15). The experimental groups was treated for 8 sessions, one session of 90 minutes per week. The control group received no intervention. Parents completed the Psychological Distress Scale, Body Image Concern Inventory and the Physical Symptoms Questionnaire with Psoriasis Area Severity Index before and after the treatment sessions. The data were analyzed by Analysis of covariance. 

The findings showed that cognitive-behavioral and emotion-focused reduced psychological distress (P<0.01, F=21.06), improved perception of body image (P<0.01, F=33.65) and reducing the severity of psoriasis symptoms (P>0.01, F=12.67) are effective. Also, cognitive behavioral therapy is more effective method to reduce psychological distress and improve perception of body image (P<0.01). However, there is no significant difference between the effectiveness of cognitive-behavioral therapy and emotion-focused therapy in reducing psoriasis symptoms of patients (P<0.05).

Both therapies can play a key and effective role in controlling the symptoms of psoriasis.

The human face is the main source of information transmission for many non-verbal messages, including the emotional state of a person. Botox or botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum that grows and reproduces in canned foods. There are 8 serotypes of this toxin, the B type is mainly used clinically to treat a wide range of disorders and diseases, and the A type is used for cosmetic purposes. Repeated injections of Botox are necessary to maintain its therapeutic effects. Botox injection in the muscles located under the wrinkles of the face causes them to relax and as a result the skin of that part becomes smooth. Botox injection in therapeutic or cosmetic cases is relatively safe and can be an alternative method to the use of drugs or surgery. Although the frequency of serious side effects for the use of Botox in medical cases is much higher than in cases of cosmetic use. However, the use of Botox in beauty may also have side effects that can be avoided by following different techniques.

Treatment of chronic conditions like diabetic foot ulcer (DFU) is challenging due to increased susceptibility for infection and delayed wound healing. Complexity of existing therapy, adverse effects and microbial resistance emphasizes the need of an alternative approach for the management of DFU. The increasing body of evidence associated with probiotic application in diverse disease states merits its use in wound healing and infection too. Different probiotic strains have shown their efficacy in various infections like gut infections, oral infections and urogenital infections. Experimental studies have demonstrated probiotics’ ability for gastric ulcer healing. Underlying mechanism of the above therapeutic effects of probiotics involves modulation of local and systemic immunity. The hypothesis is based on the concept that mechanism of anti-infective and ulcer healing action of probiotics will be similar in peripheral wounds and ulcers as on any other part of the body. This paper focuses on the hypothesis that topical formulation of probiotics may be effective for the treatment of diabetic foot ulcers.

Chondroidsyringoma or apocrine mixed tumor is a benign skin tumor that usually manifests as a nodular lesion with slow growth and no symptoms in the head and neck area, and based on histologicalcharacteristics, it can be apocrine or eccrine. Tumor diagnosis is based on clinical features and histopathology and its treatment is surgical removal of the lesion.

Case report:

 In this study, we report a case of apocrine chondroidsyringoma in a 33-year-old man who presented with a complaint of an asymptomatic nodular lesion in the area above the upper lip, and after biopsy and histopathological examination, the diagnosis of apocrine chondroidsyringoma was made.

Chondroidsyringoma does not have a specific clinical manifestation and its diagnosis is challenging and is based on attention to histological features in addition to clinical manifestations. This tumor should be considered in the differential diagnosis for subcutaneous nodules, especially in the head and neck area.