مجله دانشگاه علوم پزشکی شهید صدوقی یزد
سال سی و یکم شماره 7 (پیاپی 203، مهر 1402)

 Premature Ovarian Failure (POF) is a disease that occurs before the age of 40 due to dysfunction of the ovaries. In these women، the production and secretion of estrogen hormone is not done properly. Such a situation causes irregular or interrupted periods، disturbances in the ovulation process and occurrence of menopausal symptoms. Premature ovarian failure makes it difficult for women to get pregnant، so more research in this field is necessary.

 The results showed that one of the recommended ways to repair and regenerate the failing ovarian tissue was the use of platelet-rich plasma (PRP). The positive effects of PRP were dependent on the high concentration of growth factors in the alpha granules of platelets. The results of this review article showed that the use of platelet-rich plasma in restoring ovarian function could be considered as a treatment method in these patients.

Tuberculosis is one of the most common infections that lead to death,; incidence of tuberculosis is higher in individuals with immune system deficiency. Candidates for receiving immunosuppressive drugs should be examined for the presence of latent tuberculosis, so that if this test is positive, appropriate treatment and prophylaxis measures for tuberculosis can be carried out for them. The purpose of this study was to screen patients who are candidates for receiving immunosuppressive drugs in terms of tuberculosis.

This cross-sectional study was conducted on the patients who were candidates for injectable immunosuppressive drugs hospitalized in Shahid Sadoughi Hospital between 2019 to 2020. Tuberculin skin test (TST) was taken from all eligible patients by the infection control unit of the hospital. Statistical analysis was done by SPSS V16. The P value less than 0.05 was considered statistically significant.

Participants were divided into three groups: healthy (TST=0-4), suspected (TST=5-9) and infected with tuberculosis (TST≥10); the frequency in the three groups was 83 (23.9%), 164 respectively. (47.3%) and 100 (28.8%). There was a significant relationship between the reason for referral to receive immunosuppressive drugs and the results of the TST test (P=0.003).

If the patients with rheumatology, dermatology disorders and kidney transplant candidates receive immunosuppressive drugs, they are at high risk of primary tuberculosis infection and activation of latent tuberculosis, and it is necessary for health workers to pay more attention to this issue.

Cardiovascular diseases, including ischemic heart disease (IHD), are one of the main cause of mortality and morbidity worldwide and are currently one of the top ten causes of death. Ischemic heart disease is a type of heart disease that is caused by narrowing of arteries feeding the heart itself. The present study aimed to use data mining algorithms in screening and early prediction of IHD according to the patient's characteristics and risk factors.

In this research, data of the first phase of Yazd Health Study (YaHS), focusing on 21 characteristics of 10,000 participants aged 20-70 years such as age, type of chest pain, blood sugar level, body mass index, employment status, etc. which have been collected since 2013 were analyzed.

Data analysis was conducted using Random Forest and Naive Bayes algorithms which showed 74.51% accuracy in predicting IHD.

The study findings revealed that via applying Random Forest and Naive Bayes algorithms, ischemic heart disease can be predicted with high accuracy. Moreover, early screening and timely treatment in the early stages of disease may reduce mortality and morbidity.

The third root of mandibular molar teeth is the most important normal anatomical variation in these teeth. Failure to recognize the presence of this root is one of the most common reasons for treatment failure in these teeth. Therefore, the aim of this study was to investigate the prevalence of Radix Entomolaris in the mandibular first and second molars in the population of Yazd City using CBCT imaging.

In this study, 217 CBCT images prepared in an oral and maxillofacial radiology clinic were examined. The presence of the third root in the first and second molar teeth of the mandible was investigated according to the gender of the patients and the side of the tooth placement. Data were analyzed using SPSS16 software and Chi-Square statistical test. 

The prevalence of Radix Entomolaris in the present study in first molar and second molar teeth was recorded 5.1% and 1.8%, respectively. It was reported that its bilateral prevalence was 1.4%. In unilateral cases it was observed more on the right side. The occurrence of Radix Entomolaris had no statistically significant relationship with gender (P>0.05).

The overall frequency of Radix Entomolaris in the population of Yazd City is 6.9%. Its frequency is more likely to be unilateral, mostly in the first molar and without the influence of gender.

Microleakage is one of the most important factors in the failure of root canal treatment. Microhardness is one of the physical properties of bioceramics that can be affected by various environmental factors such as enviromental humidity. The aim of this study was to evaluation the effect of adding water to semi-setting cement on the microhardness and microleakage of CEM cement.

50 single-rooted teeth were selected. Teeth were cut from the CEJ region and the apical 3 mm of the root were trimmed and dentinal blocks with 5 mm height were prepared Peeso reamer size 2 was used to prepare the canal. The teeth were divided into two groups of 23 cases and two groups of 2 positive and negative controls. In the first group, CEM-cement prepared according to the manufacturer's instructions was placed in the canal. In the second group, after adding water to the semi-setting CEM cement mixture, the canal was filled with this cement. The samples were placed in 1% methylene blue for 3 days and then cut. Microleakage was recorded under a stereomicroscope. The microhardness of the samples was measured with Vickers device after mounting in acrylic resin. Statistical analysis was performed using SPSS19 software and Mann-Whitney Kruskal-Wallis and one-way ANOVA tests.

There was a statistically significant difference between the two groups in microleakage (P-Value <0.008) and microhardness (P-Value <0.001).

According to the results of the present study, adding water to the semi-setting CEM cement not only does have a very bad clinical effect, but also may even increase sealling ability.

One of the serious challenges that societies all over the world are facing is the tendency of couples to have fewer children and to delay it. It is possible thatcovid-19 pandemic, in addition to the previous reasons, attitudes and factors affecting childbearing, may make couples physically and psychologically hesitant to accept the role of parents. This study was conducted with the aim of investigating the attitude and intention to childbearing age during Covid-19 pandemic in married women of reproductive age in Yazd City in year 2022.

This descriptive-cross-sectional study was conducted from March 2022 to June 2022 on 225 married women aged 15-40 covered by comprehensive health centers in Yazd-Iran.The data were collected by completing the demographic information questionnaire, the Persian Version of Attitudes toward Fertility and Childbearing Scale that was approved in 2014 by Baezt et al.; obtaining a higher score indicated a more favorable attitude By answering to the open-ended questions, by self-reporting and electronically, the information related to the factors affecting the intention to have children was collected. The data were analyzed with SPSS16 software.

The results showed that the attitude towards having children in the research community was not favorable (66.96 ± 10.55). Economic problems (n=184, 81.1%), Covid 19 pandemic (n=129, 56.4%) and the importance to comfort and convenience of parents (n=70, 30.8%) was considered as one of the most important factors affecting couples intention to childbearing.

Although the spread of communicable diseases and epidemics can affect the desire of couples to childbearing, but the economic problems and the economic consequences of the pandemic, had undeniable and greater effects on the desire of families childbearing.

 Insulin injection training will lead to improved glucose control and greater satisfaction with treatment. The purpose of this study was to determine the impact of insulin injection re-education on injection errors and blood glucose control in the patients with type 2 diabetes.

This semi-experimental study was performed on 108 patients with type 2 diabetes referred to Yazd Diabetes Center using simple random sampling. The data collection tool was a researcher-made questionnaire that was completed for the patients before and three months after the intervention. The educational content was sent to the participants in the form of a five-minute video and via mobile phone. Data were analyzed using Pair t-test in SPSS 16.

The mean age of the participants was 61.44 ±8.94 years. The appropriate injection before and after the intervention in terms of the frequency of reused needle (20.4% vs 39.7% , p=0.013), keep pressing (47.2% vs 70.5%, p=0.001), size of the injection area (52.8% vs 75.3%, p=0.001), injection rotation (28.7% vs 37.2%, p=0.02 ) and insulin injection time (65.7%% vs 75.6%, p=0.04), showed a significant increase.

Insulin injection re-education can lead to reducing patients' errors related to the injection. Therefore, teaching patients at regular intervals can improve their performance in the field of insulin injection and improve the quality of treatment.

Abuse of anabolic steroids can lead to kidney tissue damage.The aim of this study was to investigate the effect of eight weeks of resistance training on inflammatory markers and antioxidant indices of kidney tissue of male rats following testosterone enanthate abuse.

In this experimental study, 24 male Wistar rats were randomly divided into three groups: 1) Control, 2) Training and 3) Training + Testosterone. Rats in groups 2 and 3 performed resistance training five sessions a week for eight weeks. Moreover, group 3 received 20 mg/kg of testosterone enanthate intramuscularly three days a week. The activity levels of Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) were measured by spectrophotometric method and the gene expression of Interleukin-6 (IL-6) and Tumor necrosis factor alpha (TNF-α) were measured by Real Time PCR method. The data were analyzed using SPSS version 16 software. To analyze the findings, To analyze the findings, one-way analysis of variance was used (P≥0.05).

Resistance training caused a significant decrease in GPx activity (P=0.001) compared to the control group. IL-6 gene expression in the training + testosterone group was significantly more than the training group (P=0.04) and the control group (P=0.001). Training + testosterone caused a significant increase in TNF-α gene expression compared to the training group (P=0.02) and the control group (P=0.008). Furthermore, the level of GPx activity in the training + testosterone group was significantly lower than the control group (P=0.001), but no significant difference was observed in the training + testosterone groups and the training group (P=0.93).

It seems that testosterone abuse along with intense resistance training is associated with a decrease in the function of the antioxidant system and increase in inflammatory markers in the kidney tissue.