mohammadreza ghadirzadeh

Given the increasing prevalence of methadone overdose and the growing number of deaths in Iran, the present study was conducted to determine the mortality rate of methadone detected in the cadavers brought to the Forensic Medicine Organization between 2015 and 2017.

This cross-sectional study was performed on 7,486 cases of substance abuse deaths registered in the Forensic Medicine Organization during 2015-2017. In order to investigate the drug abuse, samples collected from the cadavers were initially examined for their drug contents, such as methadone, by standard screening methods and then confirmed by thin layer chromatography (TLC). Using two checklists, the information collected about each cadaver consisted of the identity, autopsy and laboratory data. After data collection, they were entered into the Stata software version 14 MP.

The cadavers’ mean age was 36.6±12.6 years. Over the 3-year duration of the study, the standardized mortality rate increased from 35 to 39 cases per million per year. Of these cases, 6066 were randomly assigned to toxicology, 50.1% had used methadone one month before their death. Approximately 75% of the methadone abusers had taken another drug simultaneously, mostly morphine or methamphetamine.

Considering the relatively high prevalence of methadone detected post-mortem, monitoring for methadone entry into public market and identifying the death-related factors in the drug abusers are considered as significant measures to improve upon the current alarming situation in the Iranian society.

Using dexmedetomidine (Dex) as a sedative agent may benefit the clinical outcomes of post-surgery patients. We reviewed randomized controlled trials (RCTs) to assess whether use of a Dex could improve the outcomes in post-surgery critically ill adults.

We searched Medline, Embase, PubMed, and the Cochrane databases for RCTs comparing Dex with propofol or a placebo in post-operative patients, all included RCTs should be published in English before Jul 2016. Citations meeting inclusion criteria were full screened, and trial available data were abstracted independently and the Cochrane risk of bias tool was used for quality assessment.

Sixteen RCTs involving 2568 patients were subjected to this meta-analysis. The use of a Dex sedative regimen was associated with a reduce delirium prevalence [odd ratio (OR):0.33, 95% confidence intervals (CI): 0.24–0.45, I2= 5%, P<0.001], a shorter the length of ICU stay [mean difference (MD): -0.60, 95%CI: -0.69 to -0.50, I2=40%, P<0.001] and the length of hospital stay [MD: -0.68, 95%CI: -1.21 to -0.16, I2=0%, P=0.01]. However, using of Dex could not shorter the duration of mechanical ventilation [MD: -10.18. 95%CI: -31.08–10.72, I2=99%, P=0.34], but could shorter the time to extubation in post-surgery patients [MD: -47.46, 95%CI: -84.63–10.67, I2=98%, P=0.01].

The use of a Dex sedative regimen was associated with a reduce delirium prevalence, a shorter the length of ICU and hospital stay, and a shorter time to extubation in post-surgery critical ill patients.

The Ministry of Health and Medical Education (MOHME) and the Legal Medicine Organization (LMO) are the 2 death registration systems in Iran for registering drug-related deaths. The aim of the present study was to assess the number of undercount and the overlap between the deaths registered by the 2 sources.

In this descriptive study, according to the 10th revision of the International Classification of Diseases (ICD-10), the registered data on drug-related deaths in the years 2014-2016, as recorded by the MOHME and the LMO, were collected and the number of deaths was estimated using 2-source capture-recapture method and Excel and SPSS software.

The total number of drug-related deaths, as registered by the 2 sources, was 8639 during the 3 years. A major part of the drug-related deaths (75% of the data) had been registered by the LMO and only 25% of deaths had been registered by the MOHME. There was also a small overlap (7.7% of deaths) between the data from the 2 sources. The final estimation from the capture-recapture model and analysis of sensitivity showed that, during the 3 years, the total number of drug-related deaths was 14517 [95% confidence interval (CI):14498-14558]. Based on the complete overlap assumption and 50% of unidentified individuals in the 2 sources, the number of deaths was estimated at 11341 and 12418, respectively. The largest number of drug-related deaths had occurred within the age range of 25-39 years and in men. Kermanshah, Hamedan, and Zanjan Provinces (Iran) had the largest number of cumulative incidences of drug-related deaths. Based on the data provided by the MOHME, the most common cause of death was Methadone poisoning.

There was a small overlap between the MOHME and the LMO in the registration of drug-related deaths. Failure to enter accurate and correct information has led to miscalculations of these deaths in Iran.

Murder is one of the public health problems. According to the WHO reports, murder is fourth leading cause of death among young people. The aim of this study was applying joint point regression model to study trend of homicide mortality in Iran, 2006-2016. Study design: A cross-sectional panel (pseudo-panel) study.

Homicide data during 2006 to 2016 were extracted from Iranian legal medicine organization. Trends of homicide incidence were summarized by annual percent change (APC) and average annual percent change (AAPC) using non-linear segmented regression model.

Totally, 26918 homicide cases occurred during the period from 2006 to 2016. The highest and lowest frequency was related to the 15-29 yr (46.5%) and 0-4 yr (1.5%) age groups, respectively. The homicide incidence rate of the country in 2016 was 2.81 per 100,000. The four provinces of Sistan & Baluchistan, Khuzestan, Kerman and Ilam had the highest incidence rate in 2016, respectively. During the study period, the incidence rate of homicide in Iran and men have been significantly decreased (APC: -2.8% (95% CI: -3.9, -1.7) and -3.2% (95% CI: - 4.5, -1.8) respectively (P<0.001)).

The pattern of homicide rate has a downward trend in the country. Moreover, the varying observed trends in some provinces can be due to the variability in mental, geographical, socio-economic and cultural conditions in each region.

We aimed to investigate the suicide rate led to death in the elderly population of Iran between 2008 and 2014. Study design: A cross-sectional study.

The present study was conducted on all suicide-related deaths in elderly people (≥65 yr) during the years 2008 to 2014 reported to the Iranian Legal Medicine Organization. For data collection, legal medicine standard form was used and the cases were classified by age, gender, suicide way and time (year). The incidence of death from suicide was calculated by age and sex. Statistical soft-ware stata12 was used to analyze data. The significance level has been considered to be 0.05.

Overall, 1,601 suicide-related deaths were investigated throughout the country. The mean age was 70.36 ± 0.17 years. The incidence trend (per 100,000 people) of the elderly suicides in Iran indicates that successful suicides have been on the rise, rising from 3.7 in 2008 to 4.37 per 100,000 people in 2014.

It is necessary to identify and treat suicidal important predisposing factors of suicide such as psycho-social illnesses including depression and also implement prevention programs and policies for this fast-rising population age-group.

Road traffic accidents (RTAs) are the second cause of death, the first leading cause of years of life lost due to premature mortality, and the most common source of injury in Iran. According to the World Health Organization estimates, Iran located in the countries that have the highest rates from RTAs. The present study aimed to measure road traffic mortality rates and also to depict a view of the trend for a period of 11 years which started from 2006 to 2016.

In this cross‑sectional study, we collect data on all road traffic deaths in Iran between 2006 and 2016 using records from the Legal Medicine Organization. For doing this research, demographic and epidemiological data of the deceased were extracted using a checklist designed by the forensic experts. Content validity of this form was determined by obtaining comments of professors and scholars in the field. Directly standardized mortality rates were calculated. Finally, the information was analyzed by descriptive statistics.

During the 11‑year period of this study, 226,514 people in Iran died from RTAs. The age‑adjusted mortality rate that caused by road traffic decreased from 41.5/100,000 people in 2006 to 20.4 in 2016 during the study period. There were significant differences in mortality rates between males and females and between outside city and inside city roads. The age‑adjusted mortality rate was significantly higher among men than in women. The majority of death has occurred in illiterate young men aged 15–34 years and also in self‑employed people.

During the 2006–2016, mortality from RTAs decreased from 41.5 to 20.4/100,000 populations. This decreasing trend was observed in both sexes and in outside city and inside city roads. However, this reduction trend in the last years of the study is not suitable. These findings highlighted that training programs and harm reduction approaches for reducing the mortality from traffic accident are still needed.

Addiction disrupts the nervous system of the reward system, stimulus, and memory in the brain. The disruption of these systems in the brain causes biological, physiological, social, and psychological complications. Addiction is considered a psychological, social, and economic disorder in terms of medicine, psychology, and sociology, as well as philosophy, law, ethics, and religion. The most important place of narcotic effect is the brain, and receptors affect these substances. Dopamine and serotonin receptors are among the most important receptors, in which drugs affect them. Methadone is also an opiate drug that is even more addictive than morphine and heroin and is often used as a preservative to control heroin and narcotic addiction. In this study, 3 genes of 5-Hydroxytryptamine Receptor 2 A (5HT2Ra), 5-Hydroxytryptamine Receptor 3 A (5HT3Ra), and Monoamine Oxidases A (MAOA), which play an important role in serotonin function, were examined in Peripheral Blood Mononuclear Cells (PBMCs) of heroin addicts, who had been quitting addiction with methadone for 3 months. Therefore, peripheral blood PBMCs were isolated. cDNA was synthesized from mRNA; then, the expression of the gene was measured by real-time Polymerase Chain Reaction (PCR). The expression of MAOA gene in the PBMCs of the addicted patients with methadone was significantly reduced compared to the control group, while the expression of 5HT2Ra and 5HT3Ra genes showed no change in the two groups. These results suggest that Methadone Maintenance Treatment (MMT) may be moderated by 5HT2Ra and 5 HT3Ra serotonin receptors and returned to their previous efficacy, but MAOA was significantly reduced.

Occupational injury is a cause of premature mortality, mainly in low- and middle-income countries. Occupational injuries estimated to kill more than 300,000 workers worldwide every year. We estimated the years of life lost (YLL) of fatal unintentional occupational injuries in Iran for the five years of 2012-2016. Study design: A cross-sectional study. To estimate the YLL, registered deaths due to occupational unintentional injury were identified from the Iranian Legal Medicine Organization. Estimated YLL was calculated according to Global Burden of Disease 2010 guideline. Population life expectancy in each corresponding years was retrieved from the national health database. All data collected entered into Excel software for calculations. In 2012-2016, fatal unintentional occupational injuries were the cause of 8,606 deaths in Iran, resulting in 4.6 prematurely lost life yr per 1000 males and 0.3 yr per 1000 females among workers, every year. 98.7% of the deaths occurred in males. Males from 15 to 19 yr of age and females from 10 to 14 yr of age showed the highest YLL rates. The rate of YLLs per 1,000 workers per year was 3.99 overall, 4.6 in males, and 0.4 in females. Premature mortality due to occupational injury is still a serious problem in the Iranian population. Our findings may be useful from a health policy perspective for designing and prioritizing interventions focused on the prevention of premature loss of life. Known prevention strategies need to be implemented widely to diminish avoidable injuries in the workplace.

Medications nowadays have been commonly used items in the world and are sometimes available without prescription. This causes a range of effects on public health. This study evaluated the frequency and the involved factors of uncontrolled prescription drugs consumption. The present study is a cross-sectional study on 1,000 citizens of Tehran between 2016 and 2017. The various factors such as age, gender, and educational background have been carefully surveyed. The questionnaires were presented to interested people in printed form. For analyzing the data, descriptive statistics and analytical statistics were performed using SPSS software version 19. 67% of participants use OTC drugs and 34% of them were between 20 and 30 years old. Although 12% of the OTC pills were used regularly as a pain killer, 95% of the people did not know anything about the side effects of the drugs. Moreover, 45% used the pill to relieve the common and acute pain and 34% of people lived in poverty and 12% suggested lack of adequate time as a reason to refuse visiting a doctor. Self-administered drug is one of the problems in the medical field. Headache is the main reason of self-medication. In the other hand, drug resistance is also rising among repeated drug users. According to the results, public education, the prohibition of the sale of some high-risk drugs and the reduction of drug doses are ways to prevent the development of such high-risk habits.

Addiction and drug misuse is an illness that affects every community in every country. Based on the previous research in many parts of the world, illicit drug use is considered as a well-known risk factor for morbidity, disability, and premature mortality. Although this issue is a hot topic for public health, little studies have looked the epidemiology of substance abuse death and its trends among Iranian society. This study aims to calculate the rate of substance misuse mortality and investigate its trend in Iran. This research was a cross-sectional study. For doing this study, the demographic and epidemiological data of people who died from substance misuse from 2014-2018 were extracted from Legal Medicine Organization (LMO). Finally, descriptive statistics were used to analyze the data. 15304 deaths due to drug misuse were recorded in 2014-2018. The substance abuse mortality rate has increased during the study period in men and women. There were significant differences in death rates between men and women. Crude mortality rate was significantly higher among men compared to women. The majority of deaths has occurred in young men aged 30-39 years with high school education and self-employed. The results revealed that death from substance misuse has increased during the study period. This increasing trend was observed in women and men. Further preventive measures, however, should be devised to reduce drug-related deaths. The majority of deaths occurred in young men aged 30-39 years with high school education and self-employed. In our opinion and based on the study results, programs, policies, and preventive measures should be taken to prevent these people from accessing and using the drug.

Substance abuse in drivers is a global public health concern. We investigated patterns of alcohol and illicit drug consumption in drivers died in traffic accidents in Tehran Province, Iran. In this cross-sectional study, presence of alcohol and illicit drugs in the body of dead drivers referred to Tehran Legal Medicine Organization during April 2016 to April 2018 were investigated. All participants underwent autopsy and their urine, visceral and vitreous samples were examined for alcohol and illicit drugs. Victims with Complete Toxicology Tests for both alcohol and non-alcoholic drugs and those autopsied during their first 24 hours of death were included. Victims’ demographic characteristics, results of their toxicology tests and accident-related factors were investigated, too. To warrant confidentiality of information, identities of victims were concealed. The obtained data were analyzed by SPSS V. 16 and statistically significant level was set at less than 0.05. Of 618 study participants (mean age of 36.95 years), 601 (97.3%) were male. Of victims, 566 (91.3%) were city inhabitants and 471 (76.2%) were with educational attainment of lower than high school. The majority (93%) of crashes happened inside the city. Causes of death were head trauma in 519 (84%) cases, multiple traumas in 62 (10%) cases and bleeding in 37 (6%) cases. Multiple and single-vehicle accidents account for 498 (80.5%) and 98 (17.5%) crashes, respectively. A total of 73 (11.8%) cases were found positive for alcohol/drug consumption: 24 (4%) were alcohol positive, 52 (8.4%) were positive for non-alcoholic drugs (3 were positive for both). Main detected non-alcoholic drugs were morphine and tramadol. There was statistically significant association between drug/alcohol consumption of drivers and cause of death and crash mechanism (Both P<0.001). Multiple traumas and single vehicle crashes were more prevalent among drivers with drug/alcohol positive tests. Rate of alcohol use in our drivers was lower than many countries which is attributed to religious and legal issues. Consistent with the reported pattern of drug abuse in Iranian general population, opioids and tramadol were the main drugs of abuse among studied drivers. Drug or alcohol use result in drivers’ distraction and more fatal injuries.

  The present study aimed to evaluate the epidemiology of mortality due to substance abuse to provide useful information for local, national, and international administrators. This cross-sectional study was carried out in 12 months from March 2016 to February 2017. The study population was a random sample of people who died from substance abuse. Data were collected by checklists which were designed according to the study objectives. The obtained data were analyzed in Stata software. Our findings show that the mortality rate for illicit opiate users was 40.90 per 1000000 population. Most deaths occurred among people aged 30 to 39 years (25%), single (46.75%) with low education levels. Kermanshah, Lorestan, and Alborz provinces had the highest mortality rate. History of overdose, suicide, hospitalization in psychiatric in hospital and incarceration was observed in some people who died from substance abuse. A large number of deaths from drug abuse occurred in unmarried, self-employed, young males 30 to 39 years old with low education levels. We suggest that training programs and harm reduction approaches be focused in these high risk groups

Road traffic accident (RTA) is one of the major public health problems. Inequality in this problem and its trend has not been yet investigated in Iran. A better understanding of different contributing factors to RTA like inequalities can be helpful to reduce the negative influence of road crashes. Hence, this study aimed at examining geographical inequality in mortality from RTAs over the previous decades. In this cross-sectional study, all people who died from RTAs from March 2006 to February 2015 were selected. The data were taken from Legal Medicine Organization in Iran. The Theil index was used to estimate geographical inequality in mortality from RTA. Data were then analyzed using the Stata software. During the 10-year period of this study, 210,582 people in Iran died due to RTA. The mortality rate that caused by RTAs has decreased during the study. We found a larger reduction in a mortality rate in suburban RTAs. In spite of the reduction in RTAs death, geographical inequality increased during the 10-year study. The findings of this study indicate that there is a geographical inequality in mortality from RTAs in Iran. This implies that effective interventions in reducing the RTAs should be distributed equally among regions of the country. Further research can be performed to investigate the causes of this inequality.

Due to the high rate of pedestrian deaths in traffic accidents and given that describing demographic profiles of pedestrian deaths and features of accident locations is an important factor in the prevention, management, and analysis of road traffic accidents, this study aimed at describing the demographic and personal patterns as well as environmental factors affecting the occurrence of road traffic accidents among pedestrians in Iran.
This cross-sectional study was conducted on all pedestrian deaths caused by traffic accidents referred to the Forensic Medicine Organization in Iran from March 20, 2012, to March 19, 2013. In this study, demographic information as well as the information related to the accidents and other information including trauma location, the final cause of death, date of accident, date of death, time of death, and time of accident were examined. The information received from the Forensic Medicine Organization was first controlled and then analyzed using the Stata 11 software.
From a total of 4371 pedestrians died in 2012 due to traffic accidents, 3201 cases (73.2%) were males with a mean age of 48.1 ± 0.46 years, and 1170 cases (23.8%) were females with the mean age of 46.1 ± 0.77 years. In terms of age, education, and marital status, the highest frequencies of pedestrian deaths were, respectively, observed in the age group 65 years old and above (33.4%), the illiterate group (44.5%), and married people (67.9%). The highest and the lowest incidence rates of death were seen in Gilan (11 per 1000 people) and South Khorasan Provinces (2.4 per 100,000), respectively.
Pedestrians as the most vulnerable people in traffic accidents comprise a large proportion of deaths and disabilities caused by road traffic accidents. It seems necessary to take some measures including paying special attention to physiological characteristics of the age group above 65 years old, doing close monitoring by the traffic police in October and the rush hours, and providing facilities for pedestrians to cross in busy locations of suburban areas.

The estimate of mortality associated with illicit opiate use provides useful information to those directing and monitoring local, national and international policies and programs. This study investigated the epidemiology of mortality due to the illegal consumption of narcotics and psychotropic substances in the Iran to provide evidence-based public health data for useful programs and actions aimed at preventing drug-related mortality.
Study Design: A cross-sectional study.
The information regarding all cases of psychotropic positive was collected from Legal Medicine Organization, occurred on Mar 2015 to Feb 2016. Demographic and epidemiological data were extracted from recorded documents. Data were then analyzed in Stata software.
Overall, 2306 died cases from opioid or psychotropic abuse were evaluated. The mean age of the subjects was 36.07±12.61 yr, they were mostly single male, and 88.64% of them had Iranian nationality. The mortality rate from opiate and psychotropic abuse in the whole country was 38.22 per 1000000 population. The most common location of death was at home or in another private residence. History of overdose, suicide, hospitalization in psychiatric hospital, staying in prison and substance abuse in the family observed in some people who died from drug abuse.
Mortality rate from substance abuse is more among unmarried young men aged 30-39 yr with low education level also in self-employed. We suggest policies to prevent this person accessing and using drug.

Drug abuse is a severe and chronic disorder that leaves morbidity, disability and premature mortality in the society. The study of death due to substance abuse provides useful information for local, national and international administrators. Thus, by identifying the factors that have an impact on overdose-related mortality we can provide suitable intervention for vulnerable groups. The aim of this study was an investigation of mortality rate caused by consumption of narcotic and psychoactive substances in Iran.
In this cross-sectional study, demographic and epidemiological data about all people whose cause of death was substance abuse in March 2014 to February 2015 were collected from Legal Medicine Organization (LMO). Finally, the information that was extracted from two checklists was analyzed by descriptive statistics.
Findings: In this study, 2986 cases died from substances abuse were evaluated. Most deaths have befallen in unmarried young men with mean age of 36.9 ± 12.3, in the private locations. The mortality rate of drug abuse in the whole country was 38.4 per 1000000 population. The proportion of mortality was higher in Iranian nationality and in people who had a diploma and less education. History of overdose, suicide, hospitalization in a psychiatric hospital, staying in prison and substance abuse in the family were investigated in the study population.
The present study revealed that mortality rate from substance abuse is more among unmarried young men aged 30-39 years with low education level and also in the self-employed group. We suggest that policies should be taken to prevent these people from accessing and using the drug.

Deaths from traffic accidents are a major public health problem in all societies, especially in the low and middle-income countries. This study is done to investigate the epidemiology of fatal road traffic accidents in Fars province.
This cross-sectional study, we estimated the standardized mortality rate, mortality rate per month and day according to traffic level on suburban highways. We used data collected by the Traffic statistics available on the Road Maintenance and Transportation Organization website and Legal Medicine Organization from fatal road accidents analyzed by Stata-12 software. This study was funded by Shahid Beheshti University of Medical Sciences. The Ethics Committee of Shahid Beheshti University of Medical Sciences approved the study.
: In the year 2012, total 1379 deaths occurred due to road accidents in Fars province. The age-adjusted incidence rate of fatal traffic accident was 30.02/100000 and mean of age was 36.66 ± 20.45. The mortality rate was higher in men (77/81%) and self-employed, in the age group 25-34 years, married and illiterate. Most of the decedents at during the accident and died due to head injury. The most of the fatalities were related to drivers (43/65 %), followed by the vehicle occupants (35/75 %). Considering the traffic rate on suburban roads, the highest death rate occurred in the September month, 4 o’clock AM and Abade-Shahreza and Shiraz-Marvdasht-Saadatshahr pivots occurred in the province.
Due to the high incidence and high prevalence and deaths by self-employed driver’s suburban routes, preventive measures such as precise traffic surveillance and enforcement the regulations for safe driving are considered essential.

Traffic accidents are responsible for 2.1% of the all-causes mortality and 23% of injury related deaths in the world. Iran has been recognized as one of the countries with highest cases of traffic accidents and mortality related to it. Considering the fact that mortality following traffic accidents is high in khorasan Razavi province,we investigated the epidemiology of these accidents in this province.
In this cross-sectional study, all the information of deaths caused by traffic accidents in khorasan Razavi province in the 2012 that were reported by the Legal Medicine Organization were used. At first the all of received data were controlled, and then were analyzed using the statistical software Stata 11 epidemiological variables. The relationship between some of the variables affecting the accident was evaluated by statistical tests.
During the 2012, 1330 cases of deaths following traffic accidents were reported in khorasan Razavi Province. Crude mortality rate and age adjusted mortality rates was 22.20 and 23.6 per 100,000 respectively. Overall 1020 (76%) of these cases were male. The highest number of deaths, 460 (44.31%) occurred in the age group of 15-35 years old. The cause of death in 55.94% of cases was head injury. The highest percentage of deaths occurred in Shahrivar and Tir.
According to the results of this study fatal accidents were more in males, ages 15-35 years, low education, in summer and suburban streets, and it was recommended that in upcoming planning in order to reduce mortality arising from road accidents, these issues be considered further.

Traffic accidents with about 1.24 million deaths and 20 to 50 million cases of injury or disability per year are one of the most important public health challenges around the world. In Iran, traffic accidents, with an annual incidence of 32 cases per 100 thousand people, are considered as the second leading cause of death and the most common cause of injury..
This study aimed to evaluate the epidemiological pattern and mortality rate caused by traffic accidents during year 2012 in the Khuzestan province and its cities..
In this cross-sectional study, all data related to fatal traffic accident referrals to legal medicine center of Khuzestan province during year 2012 were obtained and analyzed. Road traffic accidents mortality rate during this year was calculated for the province and its cities. The data were analyzed using Stata 11 statistical software..
In 2012, one thousand and twenty deaths related to traffic accidents occurred in Khuzestan province. The incidence of deaths due to accidents in Khuzestan province was 22.5 and the standardized age of incidence was 24.3 per 100 thousand people. Regarding gender, 78.24% of the dead individuals were male and 21.76% were female. The most common final causes of death were head trauma (76.27% cases) and bleeding (12.55% cases). The most deceased people were drivers (42.55%), passengers (34.90%), and pedestrians (21.27%). The highest traffic accidents mortality rate in Khuzestan province was observed in Hoveizeh (55.43 per one hundred thousand), Omidiye (55.30 per one hundred thousand) and Ramhormuz (53.12 per one hundred thousand), and the lowest incidence rates belonged to Lali (5.35 per one hundred thousand) and Shadegan (9.78 per one hundred thousand)..
This study showed that drivers, passengers and pedestrians were the most vulnerable road users. Regarding the fact that most of them were illiterate or had primary education and were self-employed or laborers, it seems essential to develop plans not only to train the road users but also to evaluate the safety of vehicles and roads and post-accident care programs, and consequently, implement special programs fully and strictly in order to reduce traffic fatalities..

Road traffic injuries are a major cause of death and disability globally.This study is done to investigate the epidemiology of fatal road traffic accidents in the Lorestan province in 2012 according to Legal Medicine findings.
This study was a cross-sectional. In this epidemiologic study of fatal accidents in Lorestan province¡ we estimated the mortality rate, standardized mortality rate, mortality rate per month, level of education, gender, age groups , marital status and number of road traffic per month. We also investigated the distribution of deaths according to different variables using data collected by the Legal Medicine Organization from fatal road accidents during April 2012 and March 2012. Data were analyzed using statistical software Stata11.
The results showed that In the year 2012, 553 people have died due to traffic accidents in Lorestan province. The age-standardized incidence rate was 33.2 per 100000 people. Most victims were men (87/37%), and married people (65/94 %). The highest frequency was (13/61%) for the age group 20-25 years. Age average of the victims was 20.67 ± 36.74 years. Most victims died in place of the accident and because of brain injury.
According to the high incidence rate due to road traffic injury in province to it is recommended appropriate measures should be done by the related authorities.

The increasing trend of traffic accidents is one of the most serious problems of public health. The aim of this paper was to investigate the fatal traffic accidents in Kermanshah province. All research data required were obtained from Legal Medicine Organization and analyzed by Stata-11 software. Traffic statistics available on the Road Maintenance and Transportation Organization website were used to study the death rate per month and day according to traffic level on suburban highways. The incidence rate of age-standardized deaths due to road traffic accidents was 26.1per 100,000 people, and the mean age of the dead was 39.98±21.60 years. The mortality rate was higher in men, those more than 40 years old, married, illiterate and self-employed. Considering the traffic rate on suburban roads, the highest death rate occurred in the warmest months of the year during the day. Furthermore, most deaths were due to collisions and the highest frequency of death was reported for the car occupants. In most cases, head injuries and head traumas were the final cause of death. A significant correlation was reported between the type of vehicle and the cause of death and how the accident occurred (P<0.05). The mortality rate due to traffic accidents in Kermanshah province is high. Surveillance over the suburban roads in hot seasons and male drivers is of particular importance.

Northern provinces of Iran (Guilan, Golestan and Mazandaran) are among the most accident prone area of the country as they attract many tourists for their geographical and natural wonders. This study was carried out to assess the epidemiological pattern of fatal traffic accidents in Northern provinces of Iran.

We used data gathered by Forensic Medicine Organization for those who had a fatal traffic accident in Northern provinces of Iran in 2010. Analysis was performed using STATA 11. Means and proportions were used as descriptive measures. Association between categorical variables was assessed using Chi square test and Kruskal Wallis test was used for means comparison.

The age-adjusted incidence rate of fatal traffic accident was 33.4/100000 and mean of age was 39.45±0.43. Men contributed to 80.15% of deaths and drivers made 44.66% of them. In 48.92% of cases the main cause of death was head injury. Intercity travels composed 63.26% of deaths. There was a significant relationship between the type of the vehicle and the length of time between accident and death.

Risk of fatal traffic accident in northern area of Iran is higher than the total country average. The fact that young people make a high proportion of traffic deaths and head injuries is an important cause of death need to be put in perspective to improve the driving education system and safety of cars and roads and also to enforce the related laws and regulations.

The main objective of the present study was to determine the association between completed suicides and season of the year in Iran during 2006-2010. Data on completed suicides were collected by questionnaires field out by the family members of the victims in Legal Medicine Centers throughout the country over the period from 2006 to 2010. The maximum number of completed suicides (380) was observed in August, while the minimum number (231) was reported in February. Season-wise, completed suicides were most prevalent in summer (1040), whereas least prevalent in winter (726). Mean (SD) age of individuals having committed suicide was 31.5 (14.6) years. This value did not change significantly in different seasons (P=0.051); nor, was a statistically significant difference observed in the educational level and the reason for suicide across different seasons of the year. Self-immolation and toxic poisoning were found to be significantly less common in autumn and winter (P<0.05), respectively. The number of completed suicides was higher in warm seasons Season of the year had significant relationships with gender as well the method of suicide, while no significant association was observed for age, level of education, and reason for suicide.

Mortality rate in traffic accident is high for Iranian elderly. Twenty percent of elderly people are involved in traffic accident in Iran `s cities every year. This study is a descriptive cross sectional study. All data in this field from 2006 to 2008 collected from forensic medicine centers across the country and were analyzed with SPSS software. In general, 12029 deaths due to traffic accident occurred in people over 60 years old in Iran from 2006 to 2008. On average 65% of deaths were occurred in young-old: 34.5% in old group and 0.5% in the old-old group. In these years 19.2% of death in elderly people was occurred in drivers, 56.9% in pedestrians and 23.2% in occupants. On average, each year 46% of deaths in traffic accidents were happened in cities 46.3% on suburban roads, and 6.8% were occurred on rural roads. The rate of traffic accident in Iran is about 20 folds in compare to those of other countries. In years of study mortality rate in old and old-old age groups were increased and in young-old group was decreased. The frequency of deaths in elderly people due to traffic accidents was decreased in suburban roads and increased in urban roads.