جستجوی مقالات مرتبط با کلیدواژه « Frankincense » در نشریات گروه « پزشکی »

The power of chemotherapy on prolonging and improving the life of patients is undeniable, but it often consists of various side effects. Therefore, developing of effective strategies for reduction of chemotherapy drugs toxicity is necessary. Natural products including frankincense - derived products have been demonstrated to reduce chemotherapy side effects. The aim of this study was to diminish the side effects of Busulfan - Cyclophosphamide (Bu - Cy) regimen as chemotherapeutic agents with the aid of frankincense derivatives administration in the mice model.

The chemotherapy conditioning regimen was created in Female Balb / c mice by intraperitoneal injection of 60 mg Busulfan and 150 mg Cyclophosphamide per kg of mice. Frankincense derivatives including essential oil (Ess), soxhlet oil (Sox) and n-hexane extract (Ext) were extracted and injected intraperitoneally to chemo - conditioned mice.

As expected, mice treated with Bu - Cy chemotherapy had lower bone marrow cells count and spleen index compared to the control, whereas frankincense derivatives helped reducing side effects and modifying immune system and general health.

Despite that all three extracts have decreased the side effects of chemotherapy; Ext could simultaneously increase the spleen index and the bone marrow cells count and also improve the health in comparison with the negative control group.

Oleogum resins extracted from Boswellia sacra (Frankincense) and Commiphora myrrha (Myrrha) have been traditionally used to facilitate wound healing and address skin injuries. Moreover, they have anti-inflammatory, antioxidant, and antimicrobial effects. Therefore, we hypothesized that their combination can be effective in wound healing. In this study, we evaluated the effects of methanol extracts from two oleogum resins, Boswellia sacra (Frankincense) and Commiphora myrrha (Myrrha), as well as their combination on cell migration promotion and wound healing in human dermal fibroblast cells (HDFa).

The methanol extracts of B. sacra (BS) and C. myrrha (CM) and their combination were tested to determine their optimum cytoprotective concentrations using the AlamarBlue assay. The level of reactive oxygen species (ROS) was also evaluated using a DCFDA detector. To assess cell migration promotion and wound healing properties of the extracts, a scratch wound closure assay was performed in HDFa cells and the images were analyzed using ImageJ software. Western blot analysis was employed to detect the activation of fibroblast migration associated protein extracellular signal-regulated kinase (ERK).

Using the viability assay, the optimum non-cytotoxic concentrations of the extracts (10 and 20 µg/ml) were chosen to evaluate their wound healing effects on HDFa cells. BS, CM and BC at 10 and 20 µg/ml significantly reduced H2 O2 -induced ROS levels compared to the control. In the scratch assay, BS and BC, both at 10 µg/ml, could significantly reduce the average wound width compared to the control. Western blot analysis showed that CM significantly increased the pERK/ERK ratio compared to the control.

These findings suggest the beneficial effects of both frankincense and myrrh, as well as their combination, in improving proliferation, migration, and thecwound healing process in HDFa.

Hepatic encephalopathy induces cognitive disturbances. Patients show neuroinflammation due to accumulation of toxic substances. Frankincense has neuroprotective and anti-inflammatory properties. Accordingly, we intended to evaluate the impact of frankincense on memory performance, inflammation, and the amount of hippocampal neurons in bile duct-ligated rats.

The bile duct was ligated in three groups of adult male Wistar rats (BDL groups). In two of these groups, frankincense was administered (100 or 200 mg/kg; by gavage) starting from one week before surgery to 28 days after surgery. The third BDL group received saline. In the sham group, the bile duct was not ligated and the animals received saline. Twenty-eight days after surgery, spatial memory was evaluated by the Morris water maze test. Five rats from each group were sacrificed to measure the expression of the hippocampal tumor necrosis factor-alpha (TNF-α). Three rats from each group were perfused to determine the amount of hippocampal neurons. 

Bile duct ligation impaired memory acquisition, while frankincense amended it. Bile duct ligation significantly increased the expression of TNF-α. Frankincense reduced TNF-α in BDL rats, significantly. The number of neurons in the hippocampal CA1 and CA3 areas was significantly lower in the BDL group and in the group that received frankincense (100 mg/kg) equated to the sham group. Frankincense (200 mg/kg) augmented the amount of neurons in the CA1 area, slightly and in the CA3 area, significantly. 

The results indicate the anti-inflammatory and neuroprotective effects of frankincense in bile duct ligation-induced hepatic encephalopathy.

Boswellia serrata oleo‑gum‑resin (frankincense; olibanum) has anti‑inflammatory, analgesic, and antimicrobial effects. This study aimed to evaluate the clinical effectiveness of frankincense extract in the treatment of oral aphthous ulcers.

In a randomized, double-blind, placebo‑controlled clinical trial, patients with aphthous ulcers were randomly assigned to either experimental (Frankincense extract) or placebo groups to use orally disintegrating tablets (ODT) of frankincense and placebo, respectively, four times a day for 3 days. The size of aphthous ulcers and the pain severity by visual analogue scale were recorded at days 0, 2, and 4 and compared between the groups.

Twenty‑five patients in each group completed the study. Olibanum extract ODT significantly reduced the ulcer size on the second (P < 0.001) and fourth (P < 0.001) days as well as the pain score on the second (P = 0.002) and fourth (P < 0.001) days of the intervention compared to placebo. Furthermore, at the end of the intervention, the number of patients with complete ulcer healing and pain relief in the experimental group was significantly more than the placebo group (5 vs. 0, P = 0.02; and 11 vs. 0, P < 0.001, respectively).

Taking olibanum extract ODTs reduces the ulcer size and pain severity and accelerates the healing process in the oral aphthous lesions.

Medicinal plants are used for different purposes in traditional medicine. Boswellia serrata (B. serrata) from Burseracea family has been widely used for human medical purposes. This plant known as frankincense or olibanum has a resin with therapeutic properties. The main constituent of this resin is boswellic acid that plays an important role in various fields. From past to present, many studies had been shown that olibanum and its main constituent, boswellic acid, have antiinflammatory, antioxidant, antitumor, anti-arthritic, antimicrobial and anti-carcinogenic effects. In addition, many findings about effects of B. serrata and its ingredients on central nervous system (CNS) are available. Therefore, the aim of this study is to review in vivo and in vitro evidence attributed to this plant and its constituents on CNS. Databases including Web of Sciences, Scopus, PubMed and Google Scholar were explored for entries from the beginning of January 2000 until the end of November 2020. Findings reveal that B. serrata and its constituents have neuroprtotective effects and ameliorate learning and memory malfunction. These effects mainly are attributed to the antioxidant and anti-inflammatory properties of this plant.

In Iranian culture, due to some narratives from the prophet Mohammad about the use of frankincense during pregnancy for increasing IQ in children, some women consume frankincense during expectancy. This study's goal is to evaluate the relationship between frankincense used during pregnancy and the incidence of ADHD.

In this study, the case group comprised children 4-17 years old referring to Shahid Chamran Pharmacy in Yazd from summer to winter 2018 for receiving Methylphenidate, those with whom a psychologist had identified ADHD based on DSM-V factors.  The control group included children of the same age group but without ADHD. For data gathering, a checklist was used with some questions on smoking, family history of ADHD, presence/absence of a specific disease during pregnancy, frankincense used during pregnancy, and a chemical medication consumed during pregnancy.

The main result demonstrated that the children whose mothers used frankincense during pregnancy were 0.67 times less likely to be affected by ADHD than those whose mothers did not use this substance. However, the difference failed to be statistically significant (P>0.05).

Some studies report that frankincense can bear a positive effect on the development of the brain and possibly adequate formation of dendrites trees, axons and induce proper communication between them, so the impact of frankincense on the brain may be justified by its protective effect against the hyperactive child.

Inflammatory responses are the consequences of infection, injury, and tissue dysfunctions. In general, these responses associate with the inception of several diseases such as rheumatoid arthritis, diabetes, allergy, asthma, cancer, epilepsy, and Alzheimer's disease. To enhance such responses a number of synthetic drugs are widely used, including steroidal/non-steroidal components, antibodies, and cytokine inhibitors. However, prolonged use of these components may generate some side effects, including the malfunction of digestive tract, liver intoxication, kidney damage, and cardiovascular disorders. Therefore, alternative application of natural compounds, such as herbal components, against inflammatory responses might be safer and more effective. Frankincense is a gum resin with potential therapeutic effects on various diseases with signs of inflammation. Therefore, frankincense can decrease the indications of numerous illnesses with the least side effects. The identification of critical active constituents in frankincense may be useful for the development of new components with desired biological effects. In this review, the potential therapeutic effects of frankincense will be described based on its anti-inflammatory effects.

The metabolic syndrome, a cluster of metabolic disorders, includes abdominal obesity, hypertension, dyslipidemia, and hyperglycemia leading to insulin resistance, development of diabetes mellitus, and cardiovascular diseases. For the treatment of metabolic syndrome, traditional herbal medicines such as frankincense or Boswellia species have been used due to their anti-inflammatory, anti-oxidant, anti-obesity, antidiabetic, antihypertensive, and hypolipidemic properties. Based on the literature, published evidence up to 2020 about the therapeutic effects of Boswellia species  on the metabolic disorder among Medline, Scopus, and Google Scholar were precisely evaluated by keywords such as obesity, diabetes, hyperglycemia, hypertension, blood pressure, dyslipidemia, metabolic syndrome, frankincense, and Boswellia. According to the results, Boswellia species  have beneficial effects to control metabolic syndrome and its related disorders such as hyperglycemia, dyslipidemia, hypertension, obesity, diabetes, and its complications. Boswellia species  by reducing the resistance to insulin and restoring pancreatic beta cells decrease blood glucose. Also, Boswellia species  has antithrombotic and anticoagulant properties that regulate blood pressure. The anti-oxidant properties of Boswellia species  modulate the blood lipid profile via reducing TNF-α, IL-1β levels, and increasing the adiponectin level. The therapeutic and protective effects of Boswellia species  on metabolic disorders were remarkably confirmed regarding decreasing hyperglycemia, hyperlipidemia, hypertension, and obesity.

Frankincense expands memory performance in different experimental models of learning. Nevertheless, the causal molecular mechanisms have not been well investigated. The expression levels of some of the synaptic proteins might probably change following the consumption of frankincense. The present study investigated the effect of maternal injection of frankincense during gestation and lactation periods on memory performance and the mRNA expression levels of syntaxin1A and synaptophysin in the hippocampus of the offspring rats.

Adult female Wistar rats weighing 180-220g received two doses (50 or 100mg/kg) of the aqueous extract of frankincense by gavage during gestation and lactation periods for 45 consecutive days, except three days after labor. The control group received water. Spatial memory was assessed in the male offspring rats using the Morris water maze. Quantitative PCR was used to measure mRNAs expression levels of syntaxin1A and synaptophysin.

Frankincense improved spatial memory retrieval in the offspring rats. Data analysis by one-way ANOVA demonstrated that frankincense did not change the expression levels of the hippocampal syntaxin1A mRNA in the offspring rats. However, it significantly decreased the expression levels of the hippocampal synaptophysin mRNA.

The results indicate that consumption of frankincense during both gestation and lactation periods has a beneficial impact on spatial memory performance, which is accompanied by the down-regulation of the hippocampal synaptophysin mRNA. Nevertheless, this down-regulation did not change the improving effect of frankincense in memory.