Effect of Short-term Coenzyme Q10 Supplementation on Oxidative Stress Index and Total Antioxidant Capacity of Serum in Inactive Men

In accordance with limited studies about the effect of Q10 ingestion on exercise- induced oxidative stress response، this study was conducted to identify the effect of short-term coenzyme Q10 supplementation on serum total antioxidant capacity (TAC) and malondiadehyde (MDA) after one bout of aerobic exercise in a group of inactive male. Twenty male (25±3 years، body fat 13±2. %) and VO2max 39±2 ml/kg/min were allocated in two equal groups: intervention group received supplement (2. 5 mg/kg/day Coenzyme Q10) and control group received 2. 5 mg/kg/day dextrose as placebo. After the supplementation period (14 days)، all subjects were participated in aerobic exercise protocol with 75% VO2max on the treadmill for 30 minutes. Blood samples were obtained before the supplementation and also before and after the exercise protocol. Data were analyzed by repeated measure ANOVA، Bonferroni and independent t test at α≤0. 05. Coenzyme Q10 supplementation does not have a significant effect on oxidative stress index (MDA) (P>0. 05). The serum MDA level increased significantly (P<0. 05) and serum TAC decreased (P<0. 05). After one bout of aerobic exercise increase in serum MDA and reduced in TAC in the placebo group were more prominent than in supplement group (P<0. 05). The present results show that the increased resting total ant oxidative capacity following 14-days coenzyme Q10 supplementation can decrease the undesirable alterations of serum MDA in male inactive after one bout aerobic exercise.